Differential Expression and Prognostic Value of Long Non-coding RNA in HPV-negative Head and Neck Squamous Cell Carcinoma

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2018 Mar 26

PMID 29575229

Citations 18

Authors

Sulsal-Ul Haque

Liang Niu

Damaris Kuhnell

Jacob Hendershot

Jacek Biesiada

Wen Niu

Matthew C Hagan

Karl T Kelsey

Keith A Casper

Trisha M Wise-Draper

Mario Medvedovic

Scott M Langevin

Affiliations

Soon will be listed here.

Abstract

Background: Long non-coding RNA (lncRNA) has emerged as a new avenue of interest due to its various biological functions in cancer. Abnormal expression of lncRNA has been reported in other malignancies but has been understudied in head and neck squamous cell carcinoma (HNSCC).

Methods: The lncRNA expression was interrogated via quantitative real-time polymerase chain reaction (qRT-PCR) array for 19 human papillomavirus (HPV)-negative HNSCC tumor-normal pairs. The Cancer Genome Atlas (TCGA) was used to validate these results. The association between differentially expressed lncRNA and survival outcomes was analyzed.

Results: Differential expression was validated for 5 lncRNA (SPRY4-IT1, HEIH, LUCAT1, LINC00152, and HAND2-AS1). There was also an inverse association between MEG3 expression (not significantly differentially expressed in TCGA tumors but highly variable expression) and 3-year recurrence-free survival (RFS).

Conclusion: We identified and validated differential expression of 5 lncRNA in HPV-negative HNSCC. Low MEG3 expression was associated with favorable 3-year RFS, although the significance of this finding remains unclear.

Citing Articles

The Role of Biomarkers in HPV-Positive Head and Neck Squamous Cell Carcinoma: Towards Precision Medicine.

Krsek A, Baticic L, Sotosek V, Braut T Diagnostics (Basel). 2024; 14(13).

PMID: 39001338 PMC: 11241541. DOI: 10.3390/diagnostics14131448.

lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology.

Ou C, He X, Liu Y, Zhang X Genes Dis. 2023; 10(2):415-429.

PMID: 37223495 PMC: 10201560. DOI: 10.1016/j.gendis.2021.08.012.

Expression and molecular regulation of non-coding RNAs in HPV-positive head and neck squamous cell carcinoma.

Guo D, Yang M, Li S, Zhu W, Chen M, Pan J Front Oncol. 2023; 13:1122982.

PMID: 37064141 PMC: 10090466. DOI: 10.3389/fonc.2023.1122982.

Exploring the Molecular Pathogenesis, Pathogen Association, and Therapeutic Strategies against HPV Infection.

Mukherjee A, Wanjari U, Gopalakrishnan A, Kannampuzha S, Murali R, Namachivayam A Pathogens. 2023; 12(1).

PMID: 36678374 PMC: 9865103. DOI: 10.3390/pathogens12010025.

Long non-coding RNA HEIH: a novel tumor activator in multiple cancers.

Sun J, Ni M Cancer Cell Int. 2021; 21(1):558.

PMID: 34689775 PMC: 8543845. DOI: 10.1186/s12935-021-02272-5.

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