Collagen Fiber Recruitment: A Microstructural Basis for the Nonlinear Response of the Posterior Pole of the Eye to Increases in Intraocular Pressure

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2018 Mar 26

PMID 29574185

Citations 33

Authors

Ning-Jiun Jan

Ian A Sigal

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: Collagen fibers exhibit a natural waviness or crimp that largely determine the nonlinear biomechanics of soft tissue. Experimental measurements of crimp morphology in the sheep eye, and how it changes with intraocular pressure (IOP), however, are exceedingly sparse. We quantified how posterior eye crimp changes with increasing IOP. We found that the lamina cribrosa and peripapillary sclera have fundamentally different crimp, and with increasing IOP, have different proportions of fibers that straighten, or get recruited, versus remaining wavy, or in reserve. Interestingly, at physiologic IOP of 15 mmHg, both tissues had about ¾ fibers recruited and ¼ fibers in reserve, indicating there may be an optimal fraction of fibers.

Citing Articles

Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina.

Waxman S, Schilpp H, Linton A, Jakobs T, Sigal I Invest Ophthalmol Vis Sci. 2025; 66(3):1.

PMID: 40029245 PMC: 11887932. DOI: 10.1167/iovs.66.3.1.

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult.

Bansal M, Wang B, Waxman S, Zhong F, Hua Y, Lu Y Invest Ophthalmol Vis Sci. 2024; 65(13):1.

PMID: 39495185 PMC: 11539975. DOI: 10.1167/iovs.65.13.1.

Capturing sclera anisotropy using direct collagen fiber models. Linking microstructure to macroscopic mechanical properties.

Ji F, Islam M, Sebastian F, He X, Schilpp H, Wang B bioRxiv. 2024; .

PMID: 39386446 PMC: 11463644. DOI: 10.1101/2024.09.12.612702.

Morphological comparison of astrocytes in the lamina cribrosa and glial lamina.

Waxman S, Schilpp H, Linton A, Jakobs T, Sigal I bioRxiv. 2024; .

PMID: 39314351 PMC: 11418941. DOI: 10.1101/2024.09.07.610493.

Biomechanical changes of tree shrew posterior sclera during experimental myopia, after retrobulbar vehicle injections, and crosslinking using genipin.

Bianco G, Girkin C, Samuels B, Fazio M, Grytz R Sci Rep. 2024; 14(1):20667.

PMID: 39237593 PMC: 11377427. DOI: 10.1038/s41598-024-71276-8.

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