Ian A Sigal
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Explore the profile of Ian A Sigal including associated specialties, affiliations and a list of published articles.
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120
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3653
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Recent Articles
1.
Waxman S, Schilpp H, Linton A, Jakobs T, Sigal I
Invest Ophthalmol Vis Sci
. 2025 Mar;
66(3):1.
PMID: 40029245
Purpose: Although the mechanisms underlying glaucomatous neurodegeneration are not yet well understood, cellular and small animal models suggest that lamina cribrosa (LC) astrocytes undergo early morphologic and functional changes, indicating...
2.
Bansal M, Wang B, Waxman S, Zhong F, Hua Y, Lu Y, et al.
Invest Ophthalmol Vis Sci
. 2024 Nov;
65(13):1.
PMID: 39495185
Purpose: IOP-induced mechanical insult on retinal ganglion cell axons within the optic nerve head (ONH) is believed to be a key factor in axonal damage and glaucoma. However, most studies...
3.
He X, Islam M, Ji F, Wang B, Sigal I
Acta Biomater
. 2024 Oct;
190:317-328.
PMID: 39424020
Collagen fibers are the main load-bearing component of soft tissues but difficult to incorporate into models. Whilst simplified homogenization models suffice for some applications, a thorough mechanistic understanding requires accurate...
4.
Ji F, Islam M, Sebastian F, He X, Schilpp H, Wang B, et al.
bioRxiv
. 2024 Oct;
PMID: 39386446
Because of the crucial role of collagen fibers on soft tissue mechanics, there is great interest in techniques to incorporate them in computational models. Recently we introduced a direct fiber...
5.
Lu Y, Hua Y, Wang B, Zhong F, Theophanous A, Tahir S, et al.
bioRxiv
. 2024 Sep;
PMID: 39314421
Purpose: Our goal is to evaluate how lamina cribrosa (LC) oxygenation is affected by the tissue distortions resulting from elevated IOP. Design: Experimental study on monkeys. Subjects: Four healthy monkey...
6.
He X, Islam M, Ji F, Wang B, Sigal I
bioRxiv
. 2024 Sep;
PMID: 39314407
Collagen fibers are the main load-bearing component of soft tissues but difficult to incorporate into models. Whilst simplified homogenization models suffice for some applications, a thorough mechanistic understanding requires accurate...
7.
Lu Y, Hua Y, Lee P, Theophanous A, Tahir S, Tian Q, et al.
bioRxiv
. 2024 Sep;
PMID: 39314360
Insufficient oxygenation in the lamina cribrosa (LC) may contribute to axonal damage and glaucomatous vision loss. To understand the range of susceptibilities to glaucoma, we aimed to identify key factors...
8.
Waxman S, Schilpp H, Linton A, Jakobs T, Sigal I
bioRxiv
. 2024 Sep;
PMID: 39314351
Purpose: Although the mechanisms underlying glaucomatous neurodegeneration are not yet well understood, cellular and small animal models suggest that LC astrocytes undergo early morphologic and functional changes, indicating their role...
9.
Lu Y, Hua Y, Wang B, Zhong F, Theophanous A, Tahir S, et al.
Invest Ophthalmol Vis Sci
. 2024 May;
65(5):1.
PMID: 38691092
Purpose: Elevated intraocular pressure (IOP) is thought to cause lamina cribrosa (LC) blood vessel distortions and potentially collapse, adversely affecting LC hemodynamics, reducing oxygenation, and triggering, or contributing to, glaucomatous...
10.
Ji F, Islam M, Wang B, Hua Y, Sigal I
Invest Ophthalmol Vis Sci
. 2024 Apr;
65(4):35.
PMID: 38648038
Purpose: The lamina cribrosa (LC) depends on the sclera for support. The support must be provided through the LC insertions. Although a continuous insertion over the whole LC periphery is...