The Mouse Fc Receptor for IgG (Ly-17): Molecular Cloning and Specificity

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1987 Jan 1

PMID 2957319

Citations 15

Authors

P M Hogarth

M L Hibbs

L Bonadonna

B M Scott

E Witort

G A Pietersz

I F McKenzie

Affiliations

Soon will be listed here.

Abstract

A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional Fc gamma R investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgG gamma 1/2b and rabbit IgG complexes.

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