Imaging Intralesional Heterogeneity of Sodium Concentration in Multiple Sclerosis: Initial Evidence from Na-MRI

Overview

Journal J Neurol Sci

Publisher Elsevier

Specialty Neurology

Date 2018 Mar 25

PMID 29571845

Citations 8

Authors

James T Grist

Frank Riemer

Mary A McLean

Tomasz Matys

Fulvio Zaccagna

Sarah F Hilborne

Jackie P Mason

Ilse Patterson

Rhys Slough

Joshua Kaggie

Surrin S Deen

Martin J Graves

Joanne L Jones

Alasdair J Coles

Ferdia A Gallagher

Affiliations

Soon will be listed here.

Abstract

Sodium MRI (Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-naïve relapsing-remitting MS and a ring-enhancing lesion was imaged using Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p<0.01), as well as a heterogeneous distribution of both the total tissue sodium concentration and the intracellular-weighted sodium concentration.

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