2D Superparamagnetic Tantalum Carbide Composite MXenes for Efficient Breast-Cancer Theranostics

Overview

Journal Theranostics

Date 2018 Mar 21

PMID 29556347

Citations 39

Authors

Zhuang Liu

Han Lin

Menglong Zhao

Chen Dai

Shengjian Zhang

Weijun Peng

Yu Chen

Affiliations

Soon will be listed here.

Abstract

: The emergence of two-dimensional MXenes has spurred their versatile applications in broad fields, but the exploring of novel MXene-based family members and their potential applications in theranostic nanomedicine (concurrent diagnostic imaging and therapy) have been rarely explored. In this work, we report the construction of a novel superparamagnetic MXene-based theranostic nanoplatform for efficient breast-cancer theranostics, which was based on intriguing tantalum carbide (TaC) MXene and its further rational surface-superparamagnetic iron-oxide functionalization (TaC-IONP-SPs composite MXenes) for efficient breast-cancer theranostic. The fabrication of ultrathin TaC nanosheets was based on an exfoliation strategy and superparamagnetic iron oxide nanoparticles were grown onto the surface of TaC MXene according to the redox reaction of MXene. TaC-IONP MXenes were modified with soybean phospholipid (SP) to guarantee high stability in physiological conditions. The photothermal therapy, contrast-enhanced CT, T-weighted magnetic resonance imaging and the high biocompatibility of these composite nanosheets have also been evaluated at cellular level and on mice breast tumor allograft tumor model. The Ta component of TaC-IONP-SPs exhibits high performance for contrast-enhanced CT imaging because of its high atomic number and high X-ray attenuation coefficient, and the integrated superparamagnetic IONPs act as excellent contrast agents for T-weighted magnetic resonance imaging. Especially, these TaC-IONP-SPs composite nanosheets with high photothermal-conversion efficiency (: 32.5%) has achieved complete tumor eradication without reoccurrence, verifying their highly efficient breast-tumor photo-ablation performance. This work not only significantly broadens the biomedical applications of MXene-based nanoplatforms (TaC MXene) by exploring their novel family members and further functionalization strategies (magnetic functionalization in this work), but also provides a novel and efficient theranostic nanoplatform for efficient breast-cancer theranostics.

Citing Articles

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