Predicting the Time Course of Ventricular Dilation and Thickening Using a Rapid Compartmental Model

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2018 Mar 19

PMID 29550925

Citations 23

Authors

Colleen M Witzenburg

Jeffrey W Holmes

Affiliations

Soon will be listed here.

Abstract

The ability to predict long-term growth and remodeling of the heart in individual patients could have important clinical implications, but the time to customize and run current models makes them impractical for routine clinical use. Therefore, we adapted a published growth relation for use in a compartmental model of the left ventricle (LV). The model was coupled to a circuit model of the circulation to simulate hemodynamic overload in dogs. We automatically tuned control and acute model parameters based on experimentally reported hemodynamic data and fit growth parameters to changes in LV dimensions from two experimental overload studies (one pressure, one volume). The fitted model successfully predicted the reported time course of LV dilation and thickening not only in independent studies of pressure and volume overload but also following myocardial infarction. Implemented in MATLAB on a desktop PC, the model required just 6 min to simulate 3 months of growth.

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