The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2018 Mar 16

PMID 29540995

Citations 16

Authors

Sabine Grosch

Alice V Alessenko

Elisabetta Albi

Affiliations

Soon will be listed here.

Abstract

This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process. We summarize the emerging data that support the different roles of the sphingolipid members in specific phases of inflammation: (1) migration of immune cells, (2) recognition of exogenous agents, and (3) activation/differentiation of immune cells.

Citing Articles

Functional Insights into the Sphingolipids C1P, S1P, and SPC in Human Fibroblast-like Synoviocytes by Proteomic Analysis.

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The Role of Lipids in the Regulation of Immune Responses.

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Ceramide releases exosomes with a specific miRNA signature for cell differentiation.

Fiorani F, Domenis R, Dalla E, Cataldi S, Conte C, Mandarano M Sci Rep. 2023; 13(1):10993.

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Zymosan-Induced Murine Peritonitis Is Associated with an Increased Sphingolipid Synthesis without Changing the Long to Very Long Chain Ceramide Ratio.

Pierron A, Guzylack-Piriou L, Tardieu D, Foucras G, Guerre P Int J Mol Sci. 2023; 24(3).

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Glycosphingolipids in Diabetes, Oxidative Stress, and Cardiovascular Disease: Prevention in Experimental Animal Models.

Balram A, Thapa S, Chatterjee S Int J Mol Sci. 2022; 23(23).

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