Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Mar 15

PMID 29534532

Citations 8

Authors

Consolacion Garcia-Contreras

Marta Vazquez-Gomez

Laura Torres-Rovira

Jorge Gonzalez

Esteban Porrini

Magali Gonzalez-Colaco

Beatriz Isabel

Susana Astiz

Antonio Gonzalez-Bulnes

Affiliations

Soon will be listed here.

Abstract

Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition, antioxidant status and lipid peroxidation, development of metabolic disturbances and structural changes in tissues and organs. Iberian sows with clinical evidence of aging-related sarcopenia were fed a standard diet fulfilling their maintenance requirements or an obesogenic diet for 100 days. Aging and sarcopenia were related to increased lipid accumulation and cellular dysfunction at both adipose tissue and non-adipose ectopic tissues (liver and pancreas). Obesity concomitant to sarcopenia aggravates the condition by increasing visceral adiposity and causing dyslipidemia, insulin resistance and lipotoxicity in non-adipose tissues. These results support that the Iberian swine model represents certain features of sarcopenia and sarcopenic obesity in humans, paving the way for future research on physiopathology of these conditions and possible therapeutic targets.

Citing Articles

Retinoic acid enhances ovarian steroidogenesis by regulating granulosa cell proliferation and MESP2/STAR/CYP11A1 pathway.

Cai S, Chen M, Xue B, Zhu Z, Wang X, Li J J Adv Res. 2023; 58:163-173.

PMID: 37315842 PMC: 10982869. DOI: 10.1016/j.jare.2023.06.002.

A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption.

Zhu H, Sun Q, Tang H, Chen Y, Tan K, Xu X Biogerontology. 2023; 24(2):235-244.

PMID: 36607484 DOI: 10.1007/s10522-022-10010-1.

Obesity Development and Signs of Metabolic Abnormalities in Young Göttingen Minipigs Consuming Energy Dense Diets Varying in Carbohydrate Quality.

Curtasu M, Hedemann M, Laerke H, Bach Knudsen K Nutrients. 2021; 13(5).

PMID: 34066330 PMC: 8148203. DOI: 10.3390/nu13051560.

Uterine Insulin Sensitivity Defects Induced Embryo Implantation Loss Associated with Mitochondrial Dysfunction-Triggered Oxidative Stress.

Chen M, Li J, Zhang B, Zeng X, Zeng X, Cai S Oxid Med Cell Longev. 2021; 2021:6655685.

PMID: 33953835 PMC: 8057892. DOI: 10.1155/2021/6655685.

Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring.

Heras-Molina A, Pesantez-Pacheco J, Astiz S, Garcia-Contreras C, Vazquez-Gomez M, Encinas T Animals (Basel). 2020; 10(11).

PMID: 33105758 PMC: 7690598. DOI: 10.3390/ani10111946.

References

Poudyal H, Brown L . Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity. Endocr Metab Immune Disord Drug Targets. 2011; 11(3):217-31. DOI: 10.2174/187153011796429826. View

Bouchonville M, Villareal D . Sarcopenic obesity: how do we treat it?. Curr Opin Endocrinol Diabetes Obes. 2013; 20(5):412-9. PMC: 4046899. DOI: 10.1097/01.med.0000433071.11466.7f. View

Batsis J, MacKenzie T, Lopez-Jimenez F, Bartels S . Sarcopenia, sarcopenic obesity, and functional impairments in older adults: National Health and Nutrition Examination Surveys 1999-2004. Nutr Res. 2015; 35(12):1031-9. PMC: 4825802. DOI: 10.1016/j.nutres.2015.09.003. View

van Geenen E, Smits M, Schreuder T, van der Peet D, Bloemena E, Mulder C . Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas. 2010; 39(8):1185-90. DOI: 10.1097/MPA.0b013e3181f6fce2. View

Castillo E, Goodman-Gruen D, Kritz-Silverstein D, Morton D, Wingard D, Barrett-Connor E . Sarcopenia in elderly men and women: the Rancho Bernardo study. Am J Prev Med. 2003; 25(3):226-31. DOI: 10.1016/s0749-3797(03)00197-1. View

Sanyal D, Mukherjee P, Raychaudhuri M, Ghosh S, Mukherjee S, Chowdhury S . Profile of liver enzymes in non-alcoholic fatty liver disease in patients with impaired glucose tolerance and newly detected untreated type 2 diabetes. Indian J Endocrinol Metab. 2015; 19(5):597-601. PMC: 4566337. DOI: 10.4103/2230-8210.163172. View

Lee J, Kim S, Won Jun D, Han J, Jang E, Park J . Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World J Gastroenterol. 2009; 15(15):1869-75. PMC: 2670415. DOI: 10.3748/wjg.15.1869. View

Torres-Rovira L, Astiz S, Caro A, Lopez-Bote C, Ovilo C, Pallares P . Diet-induced swine model with obesity/leptin resistance for the study of metabolic syndrome and type 2 diabetes. ScientificWorldJournal. 2012; 2012:510149. PMC: 3354447. DOI: 10.1100/2012/510149. View

Barbero A, Astiz S, Lopez-Bote C, Perez-Solana M, Ayuso M, Garcia-Real I . Maternal malnutrition and offspring sex determine juvenile obesity and metabolic disorders in a swine model of leptin resistance. PLoS One. 2013; 8(10):e78424. PMC: 3813450. DOI: 10.1371/journal.pone.0078424. View

10.

Torres-Rovira L, Gonzalez-Anover P, Astiz S, Caro A, Lopez-Bote C, Ovilo C . Effect of an obesogenic diet during the juvenile period on growth pattern, fatness and metabolic, cardiovascular and reproductive features of Swine with obesity/leptin resistance. Endocr Metab Immune Disord Drug Targets. 2012; 13(2):143-51. DOI: 10.2174/1871530311313020002. View

11.

Ruckert I, Heier M, Rathmann W, Baumeister S, Doring A, Meisinger C . Association between markers of fatty liver disease and impaired glucose regulation in men and women from the general population: the KORA-F4-study. PLoS One. 2011; 6(8):e22932. PMC: 3151286. DOI: 10.1371/journal.pone.0022932. View

12.

Olivares A, Rey A, Daza A, Lopez-Bote C . High dietary vitamin A interferes with tissue α-tocopherol concentrations in fattening pigs: a study that examines administration and withdrawal times. Animal. 2012; 3(9):1264-70. DOI: 10.1017/S175173110900487X. View

13.

Goldberg R . Lipid disorders in diabetes. Diabetes Care. 1981; 4(5):561-72. DOI: 10.2337/diacare.4.5.561. View

14.

Cusi K . Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology. 2012; 142(4):711-725.e6. DOI: 10.1053/j.gastro.2012.02.003. View

15.

Hermans M, Ahn S, Rousseau M . The atherogenic dyslipidemia ratio [log(TG)/HDL-C] is associated with residual vascular risk, beta-cell function loss and microangiopathy in type 2 diabetes females. Lipids Health Dis. 2012; 11:132. PMC: 3539971. DOI: 10.1186/1476-511X-11-132. View

16.

Corcoran M, Lamon-Fava S, Fielding R . Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise. Am J Clin Nutr. 2007; 85(3):662-77. DOI: 10.1093/ajcn/85.3.662. View

17.

Mlinar B, Marc J . New insights into adipose tissue dysfunction in insulin resistance. Clin Chem Lab Med. 2011; 49(12):1925-35. DOI: 10.1515/CCLM.2011.697. View

18.

A S . Discovering Biomarkers within the Genomic Landscape of Renal Cell Carcinoma. J Kidney. 2016; 2(1). PMC: 4836862. DOI: 10.4172/jok.1000115. View

19.

Karakelides H, Nair K . Sarcopenia of aging and its metabolic impact. Curr Top Dev Biol. 2005; 68:123-48. DOI: 10.1016/S0070-2153(05)68005-2. View

20.

Burton L, Sumukadas D . Optimal management of sarcopenia. Clin Interv Aging. 2010; 5:217-28. PMC: 2938029. DOI: 10.2147/cia.s11473. View