Pyoverdine, a Siderophore from Pseudomonas Aeruginosa, Translocates into C. Elegans, Removes Iron, and Activates a Distinct Host Response

Overview

Journal Virulence

Specialty Microbiology

Date 2018 Mar 14

PMID 29532717

Citations 75

Authors

Donghoon Kang

Daniel R Kirienko

Phillip Webster

Alfred L Fisher

Natalia V Kirienko

Affiliations

Soon will be listed here.

Abstract

Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.

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