Profiling Donepezil Template into Multipotent Hybrids with Antioxidant Properties

Overview

Journal J Enzyme Inhib Med Chem

Specialty Biochemistry

Date 2018 Mar 14

PMID 29529892

Citations 14

Authors

Eva Mezeiova

Katarina Spilovska

Eugenie Nepovimova

Lukas Gorecki

Ondrej Soukup

Rafael Dolezal

David Malinak

Jana Janockova

Daniel Jun

Kamil Kuca

Jan Korabecny

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist memantine. However, their therapeutic effect is only short-term and stabilizes cognitive functions for up to 2 years. Given this drawback together with other pathological hallmarks of the disease taken into consideration, novel approaches have recently emerged to better cope with AD onset or its progression. One such strategy implies broadening the biological profile of AChEIs into so-called multi-target directed ligands (MTDLs). In this review article, we made comprehensive literature survey emphasising on donepezil template which was structurally converted into plethora of MTLDs preserving anti-cholinesterase effect and, at the same time, escalating the anti-oxidant potential, which was reported as a crucial role in the pathogenesis of the Alzheimer's disease.

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