Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Mar 10

PMID 29520262

Citations 12

Authors

Valentin Schatz

Patrick Neubert

Franz Rieger

Jonathan Jantsch

Affiliations

Soon will be listed here.

Abstract

Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in -infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses.

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