A Compendium of Proteins That Interact with HIF-1α

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 2017 Mar 25

PMID 28336293

Citations 54

Authors

Gregg L Semenza

Affiliations

Soon will be listed here.

Abstract

Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O-dependent or O-independent manner.

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