RNA Helicase, DDX27 Regulates Skeletal Muscle Growth and Regeneration by Modulation of Translational Processes

Overview

Journal PLoS Genet

Specialty Genetics

Date 2018 Mar 9

PMID 29518074

Citations 25

Authors

Alexis H Bennett

Marie-Francoise ODonohue

Stacey R Gundry

Aye T Chan

Jeffrey Widrick

Isabelle Draper

Anirban Chakraborty

Yi Zhou

Leonard I Zon

Pierre-Emmanuel Gleizes

Alan H Beggs

Vandana A Gupta

Affiliations

Soon will be listed here.

Abstract

Gene expression in a tissue-specific context depends on the combined efforts of epigenetic, transcriptional and post-transcriptional processes that lead to the production of specific proteins that are important determinants of cellular identity. Ribosomes are a central component of the protein biosynthesis machinery in cells; however, their regulatory roles in the translational control of gene expression in skeletal muscle remain to be defined. In a genetic screen to identify critical regulators of myogenesis, we identified a DEAD-Box RNA helicase, DDX27, that is required for skeletal muscle growth and regeneration. We demonstrate that DDX27 regulates ribosomal RNA (rRNA) maturation, and thereby the ribosome biogenesis and the translation of specific transcripts during myogenesis. These findings provide insight into the translational regulation of gene expression in myogenesis and suggest novel functions for ribosomes in regulating gene expression in skeletal muscles.

Citing Articles

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