Kidney Disease Models: Tools to Identify Mechanisms and Potential Therapeutic Targets

Overview

Journal Zool Res

Publisher Science Press

Specialties Biology
Veterinary Medicine

Date 2018 Mar 9

PMID 29515089

Citations 75

Authors

Yin-Wu Bao

Yuan Yuan

Jiang-Hua Chen

Wei-Qiang Lin

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal models have been developed to advance our understanding of human nephropathy. Among these experimental models, rodents have been extensively used to enable mechanistic understanding of kidney disease induction and progression, as well as to identify potential targets for therapy. In this review, we discuss AKI models induced by surgical operation and drugs or toxins, as well as a variety of CKD models (mainly genetically modified mouse models). Results from recent and ongoing clinical trials and conceptual advances derived from animal models are also explored.

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