Absolute Configurations of Griseorhodins A and C

Overview

Journal Tetrahedron Lett

Publisher Elsevier

Specialty Chemistry

Date 2018 Mar 6

PMID 29503481

Citations 4

Authors

Humberto E Ortega

Joao M Batista Jr

Weilan G P Melo

Jon Clardy

Monica T Pupo

Affiliations

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Abstract

The known antibiotic and cytotoxic compounds griseorhodin A () and griseorhodin C () were produced in solid culture by AB10, which was isolated from the leaf-cutter ant . Their absolute configurations were unambiguously established as 6,6a,7,8 and 6,6a,7,8, respectively, using vibrational circular dichroism (VCD) and density functional theory (DFT) calculations.

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