Calycophyllum Spruceanum (Benth.), the Amazonian "Tree of Youth" Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis Elegans

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Mar 3

PMID 29495517

Citations 9

Authors

Herbenya Peixoto

Mariana Roxo

Hector Koolen

Felipe da Silva

Emerson Silva

Markus Santhosh Braun

Xiaojuan Wang

Michael Wink

Affiliations

Soon will be listed here.

Abstract

The tree popularly known in Brazil as mulateiro or pau-mulato ( (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. The current study aims to provide the first step towards a science-based evidence of the beneficial effects of in the promotion of longevity and in the modulation of age-related markers. For this investigation, we used the model system to evaluate in vivo antioxidant and anti-aging activity of a water extract from . To chemically characterize the extract, HPLC MS (High Performance Liquid Chromatography Mass Spectrometry)/MS analyses were performed. Five secondary metabolites were identified in the extract, namely gardenoside, 5-hydroxymorin, cyanidin, taxifolin, and 5-hydroxy-6-methoxycoumarin-7-glucoside. extract was able to enhance stress resistance and to extend lifespan along with attenuation of aging-associated markers in . The demonstrated bioactivities apparently depend on the DAF-16/FOXO pathway. The data might support the popular claims of mulateiro as the "tree of youth", however more studies are needed to clarify its putative benefits to human health.

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