A Retrospective Multicenter Study of Carbon-ion Radiotherapy for Major Salivary Gland Carcinomas: Subanalysis of J-CROS 1402 HN

Overview

Journal Cancer Sci

Specialty Oncology

Date 2018 Mar 2

PMID 29493851

Citations 14

Authors

Kazuhiko Hayashi

Masashi Koto

Yusuke Demizu

Jun-Ichi Saitoh

Hiroaki Suefuji

Tomoaki Okimoto

Tatsuya Ohno

Yoshiyuki Shioyama

Ryo Takagi

Hiroaki Ikawa

Kenji Nemoto

Takashi Nakano

Tadashi Kamada

Affiliations

Soon will be listed here.

Abstract

A retrospective multicenter study was carried out to assess the clinical outcomes of carbon-ion radiotherapy for head and neck malignancies (Japan Carbon-Ion Radiation Oncology Study Group [J-CROS] study: 1402 HN). We evaluated the safety and efficacy of carbon-ion radiotherapy in patients with major salivary gland carcinoma. Sixty-nine patients treated with carbon-ion radiotherapy at four Japanese institutions were analyzed. Thirty-three patients (48%) had adenoid cystic carcinomas, 10 (14%) had mucoepidermoid carcinomas, and 26 (38%) had other disease types. Three patients (4%) had T1 disease, 8 (12%) had T2, 25 (36%) had T3, and 33 (48%) had T4. The median radiation dose was 64 Gy (relative biological effectiveness) in 16 fractions. The median gross tumor volume was 27 mL. The median follow-up period was 32.7 months. The 3-year local control rate and overall survival rate were 81% and 94%, respectively. Regarding acute toxicities, seven patients had grade 3 mucositis and seven had grade 3 dermatitis. Regarding late toxicities, one patient had grade 3 dysphagia and one had a grade 3 brain abscess. No grade 4 or worse late reactions were observed. In conclusion, definitive carbon-ion radiotherapy was effective with acceptable toxicity for major salivary gland carcinomas.

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