Seeing Cilia: Imaging Modalities for Ciliary Motion and Clinical Connections

Overview

Journal Am J Physiol Lung Cell Mol Physiol

Publisher American Physiological Society

Specialties Cell Biology
Molecular Biology
Physiology
Pulmonary Medicine

Date 2018 Mar 2

PMID 29493257

Citations 14

Authors

Jacelyn E Peabody

Ren-Jay Shei

Brent M Bermingham

Scott E Phillips

Brett Turner

Steven M Rowe

George M Solomon

Affiliations

Soon will be listed here.

Abstract

The respiratory tract is lined with multiciliated epithelial cells that function to move mucus and trapped particles via the mucociliary transport apparatus. Genetic and acquired ciliopathies result in diminished mucociliary clearance, contributing to disease pathogenesis. Recent innovations in imaging technology have advanced our understanding of ciliary motion in health and disease states. Application of imaging modalities including transmission electron microscopy, high-speed video microscopy, and micron-optical coherence tomography could improve diagnostics and be applied for precision medicine. In this review, we provide an overview of ciliary motion, imaging modalities, and ciliopathic diseases of the respiratory system including primary ciliary dyskinesia, cystic fibrosis, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.

Citing Articles

Metachrony drives effective mucociliary transport via a calcium-dependent mechanism.

Lever J, Turner K, Fernandez C, Leung H, Hussain S, Shei R Am J Physiol Lung Cell Mol Physiol. 2024; 327(3):L282-L292.

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Advancing Primary Ciliary Dyskinesia Diagnosis through High-Speed Video Microscopy Analysis.

De Jesus-Rojas W, Demetriou Z, Muniz-Hernandez J, Rosario-Ortiz G, Quinones F, Ramos-Benitez M Cells. 2024; 13(7.

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Airway ciliated cells in adult lung homeostasis and COPD.

Petit L, Belgacemi R, Ancel J, Saber Cherif L, Polette M, Perotin J Eur Respir Rev. 2023; 32(170).

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Light-sheet laser speckle imaging for cilia motility assessment.

Long K, Liu J, Shen S, Thong M, Wang D, Chen N Comput Struct Biotechnol J. 2023; 21:1661-1669.

PMID: 36874161 PMC: 9978471. DOI: 10.1016/j.csbj.2023.02.036.

Mucociliary clearance augmenting drugs block SARS-CoV-2 replication in human airway epithelial cells.

Campos-Gomez J, Fernandez Petty C, Mazur M, Tang L, Solomon G, Joseph R Am J Physiol Lung Cell Mol Physiol. 2023; 324(4):L493-L506.

PMID: 36809189 PMC: 10042606. DOI: 10.1152/ajplung.00285.2022.

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