ATF7 Mediates TNF-α-induced Telomere Shortening

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2018 Mar 1

PMID 29490055

Citations 18

Authors

Toshio Maekawa

Binbin Liu

Daisuke Nakai

Keisuke Yoshida

Ken-Ichi Nakamura

Mami Yasukawa

Manabu Koike

Kaiyo Takubo

Bruno Chatton

Fuyuki Ishikawa

Kenkichi Masutomi

Shunsuke Ishii

Affiliations

Soon will be listed here.

Abstract

Telomeres maintain the integrity of chromosome ends and telomere length is an important marker of aging. The epidemiological studies suggested that many types of stress including psychosocial stress decrease telomere length. However, it remains unknown how various stresses induce telomere shortening. Here, we report that the stress-responsive transcription factor ATF7 mediates TNF-α-induced telomere shortening. ATF7 and telomerase, an enzyme that elongates telomeres, are localized on telomeres via interactions with the Ku complex. In response to TNF-α, which is induced by various stresses including psychological stress, ATF7 was phosphorylated by p38, leading to the release of ATF7 and telomerase from telomeres. Thus, a decrease of ATF7 and telomerase on telomeres in response to stress causes telomere shortening, as observed in ATF7-deficient mice. These findings give credence to the idea that various types of stress might shorten telomere.

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References

Zhong F, Batista L, Freund A, Pech M, Venteicher A, Artandi S . TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell. 2012; 150(3):481-94. PMC: 3516183. DOI: 10.1016/j.cell.2012.07.012. View

Beck M, Schmidt A, Malmstroem J, Claassen M, Ori A, Szymborska A . The quantitative proteome of a human cell line. Mol Syst Biol. 2011; 7:549. PMC: 3261713. DOI: 10.1038/msb.2011.82. View

Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M, Poon S . Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Ageing Dev. 2010; 131(10):614-24. DOI: 10.1016/j.mad.2010.08.007. View

Pfingsten J, Goodrich K, Taabazuing C, Ouenzar F, Chartrand P, Cech T . Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell. 2012; 148(5):922-32. PMC: 3327133. DOI: 10.1016/j.cell.2012.01.033. View

Koike M, Ikuta T, Miyasaka T, Shiomi T . The nuclear localization signal of the human Ku70 is a variant bipartite type recognized by the two components of nuclear pore-targeting complex. Exp Cell Res. 1999; 250(2):401-13. DOI: 10.1006/excr.1999.4507. View

Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K . Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J. 2000; 19(11):2652-61. PMC: 212742. DOI: 10.1093/emboj/19.11.2652. View

Wang F, Podell E, Zaug A, Yang Y, Baciu P, Cech T . The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature. 2007; 445(7127):506-10. DOI: 10.1038/nature05454. View

Brennecke J, Aravin A, Stark A, Dus M, Kellis M, Sachidanandam R . Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell. 2007; 128(6):1089-103. DOI: 10.1016/j.cell.2007.01.043. View

Harley C, Futcher A, Greider C . Telomeres shorten during ageing of human fibroblasts. Nature. 1990; 345(6274):458-60. DOI: 10.1038/345458a0. View

10.

Aravind L, Koonin E . SAP - a putative DNA-binding motif involved in chromosomal organization. Trends Biochem Sci. 2000; 25(3):112-4. DOI: 10.1016/s0968-0004(99)01537-6. View

11.

Herrera E, Samper E, Blasco M . Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. EMBO J. 1999; 18(5):1172-81. PMC: 1171208. DOI: 10.1093/emboj/18.5.1172. View

12.

Wang Y, Ghosh G, Hendrickson E . Ku86 represses lethal telomere deletion events in human somatic cells. Proc Natl Acad Sci U S A. 2009; 106(30):12430-5. PMC: 2718384. DOI: 10.1073/pnas.0903362106. View

13.

Garcia-Cao M, OSullivan R, Peters A, Jenuwein T, Blasco M . Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet. 2004; 36(1):94-9. DOI: 10.1038/ng1278. View

14.

Stellwagen A, Haimberger Z, Veatch J, Gottschling D . Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev. 2003; 17(19):2384-95. PMC: 218076. DOI: 10.1101/gad.1125903. View

15.

Sano Y, Harada J, Tashiro S, Maekawa T, Ishii S . ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. J Biol Chem. 1999; 274(13):8949-57. DOI: 10.1074/jbc.274.13.8949. View

16.

Hai T, Liu F, Coukos W, Green M . Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 1989; 3(12B):2083-90. DOI: 10.1101/gad.3.12b.2083. View

17.

Callicott R, Womack J . Real-time PCR assay for measurement of mouse telomeres. Comp Med. 2006; 56(1):17-22. View

18.

Koike M, Yutoku Y, Koike A . Establishment of ku70-deficient lung epithelial cell lines and their hypersensitivity to low-dose x-irradiation. J Vet Med Sci. 2010; 73(5):549-54. DOI: 10.1292/jvms.10-0454. View

19.

Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y . Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol. 2014; 34(9):1576-93. PMC: 3993606. DOI: 10.1128/MCB.00093-14. View

20.

Rudolph K, Chang S, Lee H, Blasco M, Gottlieb G, Greider C . Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 1999; 96(5):701-12. DOI: 10.1016/s0092-8674(00)80580-2. View