Genome-wide Association Study of Maternal Genetic Effects and Parent-of-origin Effects on Food Allergy

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2018 Mar 1

PMID 29489655

Citations 14

Authors

Xin Liu

Xiumei Hong

Hui-Ju Tsai

Karen K Mestan

Min Shi

Amira Kefi

Ke Hao

Qi Chen

Guoying Wang

Deanna Caruso

Hua Geng

Yufeng Gao

Jianlin He

Rajesh Kumar

Hongjian Wang

Yunxian Yu

Tami Bartell

Xiao-Di Tan

Robert P Schleimer

Daniel E Weeks

Jacqueline A Pongracic

Xiaobin Wang

Affiliations

Soon will be listed here.

Abstract

Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete Caucasian FA trios. We identified 1 single nucleotide polymorphism with significant (P < 5×10) maternal effect on any FA (rs4235235), which is located in a noncoding RNA (LOC101927947) with unknown function. We also identified 3 suggestive (P < 5×10) loci with maternal genetic effects: 1 for any FA (rs976078, in a gene desert region on 13q31.1) and 2 for egg allergy (rs1343795 and rs4572450, in the ZNF652 gene, where genetic variants have been associated with atopic dermatitis). Three suggestive loci with PO effect were observed: 1 for peanut allergy (rs4896888 in the ADGB gene) and 2 for any FA in boys only (rs1036504 and rs2917750 in the IQCE gene). Findings from this family-based GWAS of FA provided some preliminary evidence on maternal genotypic or PO effects on FA. Additional family-based studies are needed to confirm our findings and gain new insight into maternal and paternal genetic contribution to FA.

Citing Articles

Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.

Arnau-Soler A, Tremblay B, Sun Y, Madore A, Simard M, Kersten E Allergy. 2024; 80(1):106-131.

PMID: 39698764 PMC: 11724255. DOI: 10.1111/all.16429.

Maternal influences on offspring food allergy.

Lee H, Nazmul T, Lan J, Oyoshi M Immunol Rev. 2024; 326(1):130-150.

PMID: 39275992 PMC: 11867100. DOI: 10.1111/imr.13392.

Multi-omics profiling approach in food allergy.

Devonshire A, Gautam Y, Johansson E, Mersha T World Allergy Organ J. 2023; 16(5):100777.

PMID: 37214173 PMC: 10199264. DOI: 10.1016/j.waojou.2023.100777.

Mezzavilla M, Cocca M, Delser P, Badii R, Abbaszadeh F, Hadi K BMC Genom Data. 2022; 23(1):73.

PMID: 36131251 PMC: 9490902. DOI: 10.1186/s12863-022-01087-1.

Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring.

Jiao L, Su C, Cao T, Zheng S, Walker W, Shi H Front Immunol. 2022; 13:817062.

PMID: 35281070 PMC: 8904425. DOI: 10.3389/fimmu.2022.817062.

References

Zhang W, Gamazon E, Zhang X, Konkashbaev A, Liu C, Szilagyi K . SCAN database: facilitating integrative analyses of cytosine modification and expression QTL. Database (Oxford). 2015; 2015. PMC: 4375357. DOI: 10.1093/database/bav025. View

Gupta R, Sheikh A, Strachan D, Anderson H . Time trends in allergic disorders in the UK. Thorax. 2006; 62(1):91-6. PMC: 2111268. DOI: 10.1136/thx.2004.038844. View

Howell W, Turner S, Hourihane J, Dean T, Warner J . HLA class II DRB1, DQB1 and DPB1 genotypic associations with peanut allergy: evidence from a family-based and case-control study. Clin Exp Allergy. 1998; 28(2):156-62. DOI: 10.1046/j.1365-2222.1998.00224.x. View

Hong X, Hao K, Ladd-Acosta C, Hansen K, Tsai H, Liu X . Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015; 6:6304. PMC: 4340086. DOI: 10.1038/ncomms7304. View

Hourihane J, Dean T, Warner J . Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges. BMJ. 1996; 313(7056):518-21. PMC: 2351952. DOI: 10.1136/bmj.313.7056.518. View

Dreskin S, Ayars A, Jin Y, Atkins D, Leo H, Song B . Association of genetic variants of CD14 with peanut allergy and elevated IgE levels in peanut allergic individuals. Ann Allergy Asthma Immunol. 2011; 106(2):170-2. DOI: 10.1016/j.anai.2010.11.008. View

Dreskin S, Tripputi M, Aubrey M, Mustafa S, Atkins D, Leo H . Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II. Clin Immunol. 2010; 137(3):366-73. PMC: 2976616. DOI: 10.1016/j.clim.2010.08.009. View

Tsai H, Kumar R, Pongracic J, Liu X, Story R, Yu Y . Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy. 2008; 39(1):101-9. PMC: 2729087. DOI: 10.1111/j.1365-2222.2008.03111.x. View

Hong X, Tsai H, Wang X . Genetics of food allergy. Curr Opin Pediatr. 2009; 21(6):770-6. PMC: 2892276. DOI: 10.1097/MOP.0b013e32833252dc. View

10.

Sicherer S, Furlong T, Maes H, Desnick R, Sampson H, Gelb B . Genetics of peanut allergy: a twin study. J Allergy Clin Immunol. 2000; 106(1 Pt 1):53-6. DOI: 10.1067/mai.2000.108105. View

11.

Li M, Gui H, Kwan J, Sham P . GATES: a rapid and powerful gene-based association test using extended Simes procedure. Am J Hum Genet. 2011; 88(3):283-93. PMC: 3059433. DOI: 10.1016/j.ajhg.2011.01.019. View

12.

Brown S, Asai Y, Cordell H, Campbell L, Zhao Y, Liao H . Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol. 2011; 127(3):661-7. PMC: 3081065. DOI: 10.1016/j.jaci.2011.01.031. View

13.

Sampson H . Update on food allergy. J Allergy Clin Immunol. 2004; 113(5):805-19. DOI: 10.1016/j.jaci.2004.03.014. View

14.

Kelly C, Gangur V . Sex Disparity in Food Allergy: Evidence from the PubMed Database. J Allergy (Cairo). 2010; 2009:159845. PMC: 2957586. DOI: 10.1155/2009/159845. View

15.

Amoli M, Hand S, Hajeer A, Jones K, Rolf S, Sting C . Polymorphism in the STAT6 gene encodes risk for nut allergy. Genes Immun. 2002; 3(4):220-4. DOI: 10.1038/sj.gene.6363872. View

16.

Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodriguez E, Matanovic A, Marenholz I . High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet. 2013; 45(7):808-12. PMC: 3797441. DOI: 10.1038/ng.2642. View

17.

Ainsworth H, Unwin J, Jamison D, Cordell H . Investigation of maternal effects, maternal-fetal interactions and parent-of-origin effects (imprinting), using mothers and their offspring. Genet Epidemiol. 2010; 35(1):19-45. PMC: 3025173. DOI: 10.1002/gepi.20547. View

18.

Boehncke W, Loeliger C, Kuehnl P, Kalbacher H, Bohm B, Gall H . Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy. Clin Exp Allergy. 1998; 28(4):434-41. DOI: 10.1046/j.1365-2222.1998.00246.x. View

19.

Madore A, T Vaillancourt V, Asai Y, Alizadehfar R, Ben-Shoshan M, Michel D . HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy. Eur J Hum Genet. 2013; 21(10):1181-4. PMC: 3778350. DOI: 10.1038/ejhg.2013.13. View

20.

van den Oord E, Vermunt J . Testing for linkage disequilibrium, maternal effects, and imprinting with (In)complete case-parent triads, by use of the computer program LEM. Am J Hum Genet. 2000; 66(1):335-8. PMC: 1288341. DOI: 10.1086/302708. View