Peanut-allergic Subjects and Their Peanut-tolerant Siblings Have Large Differences in Peanut-specific IgG That Are Independent of HLA Class II

Overview

Journal Clin Immunol

Specialty Allergy & Immunology

Date 2010 Sep 21

PMID 20850383

Citations 10

Authors

Stephen C Dreskin

Mark T Tripputi

Michael T Aubrey

S Shahzad Mustafa

Dan Atkins

Harvey L Leo

Benjamin Song

Darcy Schlichting

Hanna Talwar

Qian Wang

Brian M Freed

Affiliations

Soon will be listed here.

Abstract

We enrolled 53 peanut-allergic subjects and 64 peanut-tolerant full siblings, measured peanut-specific IgG and IgE, determined HLA class II at high resolution, and analyzed DRB1 alleles by supertypes. Peanut-specific IgG and IgE were elevated in the peanut-allergic subjects (p<0.0001) but did not stratify with HLA alleles, haplotypes, or supertypes. There were no significant differences in HLA class II between the peanut-allergic and peanut-tolerant siblings but there was an increased frequency of DRB1*0803 in both sets of siblings compared to unrelated controls (p(c)=4.5×10⁻⁹). Furthermore, we identified 14 sibling pairs in which the peanut-allergic and the peanut-tolerant siblings have identical HLA class II and again found an elevation of anti-peanut IgG in the peanut-allergic subjects (p<0.0001). In conclusion, although DRB1*0803 may identify a subset of families with increased risk of peanut allergy, differences in peanut-specific immunoglobulin production between peanut-allergic subjects and their peanut-tolerant siblings are independent of HLA class II.

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