Inhibition of Lats1/p-YAP1 Pathway Mitigates Neuronal Apoptosis and Neurological Deficits in a Rat Model of Traumatic Brain Injury

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2018 Mar 1

PMID 29488331

Citations 9

Authors

Di Li

Jia-Xuan Ji

Yi-Tian Xu

Hai-Bo Ni

Qin Rui

Hui-Xiang Liu

Feng Jiang

Rong Gao

Gang Chen

Affiliations

Soon will be listed here.

Abstract

Aims: To investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats.

Results: We found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in injured regions were significantly increased after TBI. Furthermore, inhibition of Lats1 not only decreased the level of p-YAP1, but also attenuated neuronal apoptosis and neurological impairment.

Conclusions: Our work demonstrates that inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI.

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References

Camacho-Soto A, Warden M, Searles Nielsen S, Salter A, Brody D, Prather H . Traumatic brain injury in the prodromal period of Parkinson's disease: A large epidemiological study using medicare data. Ann Neurol. 2017; 82(5):744-754. PMC: 5812286. DOI: 10.1002/ana.25074. View

Yu F, Guan K . The Hippo pathway: regulators and regulations. Genes Dev. 2013; 27(4):355-71. PMC: 3589553. DOI: 10.1101/gad.210773.112. View

Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong J, Ikeda S . NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. Circ Res. 2016; 119(5):596-606. PMC: 4992450. DOI: 10.1161/CIRCRESAHA.116.308586. View

Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J . LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. J Cell Biol. 2012; 197(5):625-41. PMC: 3404884. DOI: 10.1083/jcb.201110110. View

Bao H, Wang T, Zhang M, Liu R, Dai D, Wang Y . Poloxamer-188 attenuates TBI-induced blood-brain barrier damage leading to decreased brain edema and reduced cellular death. Neurochem Res. 2012; 37(12):2856-67. DOI: 10.1007/s11064-012-0880-4. View

Ye X, Luo Q, Xu Y, Tang N, Niu X, Li Z . 17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway. J Cell Mol Med. 2015; 19(3):651-63. PMC: 4369821. DOI: 10.1111/jcmm.12469. View

Gong J, Li Q, Cao Y, Zheng X, Ma Y, Zhan R . Serial Attacks: Contralateral Hematoma Secondary to Decompressive Craniectomy for Traumatic Brain Injury Led to Posttraumatic Cerebral Infarction. J Craniofac Surg. 2016; 27(2):e159-62. DOI: 10.1097/SCS.0000000000002404. View

Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M . Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001; 32(4):1005-11. DOI: 10.1161/01.str.32.4.1005. View

Hopp S, Nolte M, Stetter C, Kleinschnitz C, Siren A, Albert-Weissenberger C . Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa. J Neuroinflammation. 2017; 14(1):39. PMC: 5319055. DOI: 10.1186/s12974-017-0815-8. View

10.

Chantsoulis M, Polrola P, Goral-Polrola J, Hajdukiewicz A, Supinski J, Kropotov J . Application of ERPs neuromarkers for assessment and treatment of a patient with chronic crossed aphasia after severe TBI and long-term coma - Case Report. Ann Agric Environ Med. 2017; 24(1):141-147. DOI: 10.5604/12321966.1232770 . View

11.

Camargo F, Gokhale S, Johnnidis J, Fu D, Bell G, Jaenisch R . YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol. 2007; 17(23):2054-60. DOI: 10.1016/j.cub.2007.10.039. View

12.

Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S . Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. Exp Cell Res. 2013; 319(7):931-45. DOI: 10.1016/j.yexcr.2013.01.020. View

13.

Salehi A, Zhang J, Obenaus A . Response of the cerebral vasculature following traumatic brain injury. J Cereb Blood Flow Metab. 2017; 37(7):2320-2339. PMC: 5531360. DOI: 10.1177/0271678X17701460. View

14.

Stein C, Bardet A, Roma G, Bergling S, Clay I, Ruchti A . YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers. PLoS Genet. 2015; 11(8):e1005465. PMC: 4546604. DOI: 10.1371/journal.pgen.1005465. View

15.

Yin C, Huang G, Sun X, Guo Z, Zhang J . DLK silencing attenuated neuron apoptosis through JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats. Neurobiol Dis. 2017; 103:133-143. PMC: 5493044. DOI: 10.1016/j.nbd.2017.04.006. View

16.

Leker R, Shohami E, Constantini S . Experimental models of head trauma. Acta Neurochir Suppl. 2002; 83:49-54. DOI: 10.1007/978-3-7091-6743-4_9. View

17.

Khalafian A, Dukes C, Tucker P . Consultation Dilemma Catatonia in a Patient with Prior TBI: MentaI or Medical Disorder?. J Okla State Med Assoc. 2016; 108(8):358-60. View

18.

Pang A, Xiong L, Xia Q, Liu F, Wang Y, Liu F . Neural Stem Cell Transplantation Is Associated with Inhibition of Apoptosis, Bcl-xL Upregulation, and Recovery of Neurological Function in a Rat Model of Traumatic Brain Injury. Cell Transplant. 2017; 26(7):1262-1275. PMC: 5657736. DOI: 10.1177/0963689717715168. View

19.

Vigneron A, Ludwig R, Vousden K . Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP. Genes Dev. 2010; 24(21):2430-9. PMC: 2964753. DOI: 10.1101/gad.1954310. View

20.

Li Z, Dong X, Zhang J, Zeng G, Zhao H, Liu Y . Formononetin protects TBI rats against neurological lesions and the underlying mechanism. J Neurol Sci. 2014; 338(1-2):112-7. DOI: 10.1016/j.jns.2013.12.027. View