Concurrent Renal Amyloidosis and Thymoma Resulting in a Fatal Ventricular Thrombus in a Dog

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2018 Feb 28

PMID 29485186

Citations 1

Authors

Jennifer M Loewen

Rachel E Cianciolo

Liwen Zhang

Michael Yaeger

Jessica L Ward

Jodi D Smith

Dana N LeVine

Affiliations

Soon will be listed here.

Abstract

Thymoma-associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7-year-old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome, hypercoagulability, and ventricular thrombosis. This case illustrates the potential for thymoma-associated nephropathies to occur in dogs and that dogs suspected to have thymoma should have a urinalysis and urine protein creatinine ratio performed as part of the pre-surgical database.

Citing Articles

Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog.

Loewen J, Cianciolo R, Zhang L, Yaeger M, Ward J, Smith J J Vet Intern Med. 2018; 32(3):1160-1165.

PMID: 29485186 PMC: 5980280. DOI: 10.1111/jvim.15062.

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