Development of Microspheres for Biomedical Applications: a Review

Overview

Journal Prog Biomater

Specialty Biomedical Engineering

Date 2018 Feb 23

PMID 29470791

Citations 41

Authors

Kazi M Zakir Hossain

Uresha Patel

Ifty Ahmed

Affiliations

Soon will be listed here.

Abstract

An overview of microspheres manufactured for use in biomedical applications based on recent literature is presented in this review. Different types of glasses (i.e. silicate, borate, and phosphates), ceramics and polymer-based microspheres (both natural and synthetic) in the form of porous , non-porous and hollow structures that are either already in use or are currently being investigated within the biomedical area are discussed. The advantages of using microspheres in applications such as drug delivery, bone tissue engineering and regeneration, absorption and desorption of substances, kinetic release of the loaded drug components are also presented. This review also reports on the preparation and characterisation methodologies used for the manufacture of these microspheres. Finally, a brief summary of the existing challenges associated with processing these microspheres which requires further research and development are presented.

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References

Abou Neel E, Mizoguchi T, Ito M, Bitar M, Salih V, Knowles J . In vitro bioactivity and gene expression by cells cultured on titanium dioxide doped phosphate-based glasses. Biomaterials. 2007; 28(19):2967-77. DOI: 10.1016/j.biomaterials.2007.03.018. View

Ahmed I, Lewis M, Olsen I, Knowles J . Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5-CaO-Na2O glass system. Biomaterials. 2003; 25(3):491-9. DOI: 10.1016/s0142-9612(03)00546-5. View

Yang Y, Bajaj N, Xu P, Ohn K, Tsifansky M, Yeo Y . Development of highly porous large PLGA microparticles for pulmonary drug delivery. Biomaterials. 2009; 30(10):1947-53. DOI: 10.1016/j.biomaterials.2008.12.044. View

BLAINE G . Experimental Observations on Absorbable Alginate Products in Surgery : Gel, Film, Gauze and Foam. Ann Surg. 1947; 125(1):102-14. PMC: 1803201. DOI: 10.1097/00000658-194701000-00011. View

Ungaro F, dEmmanuele di Villa Bianca R, Giovino C, Miro A, Sorrentino R, Quaglia F . Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: in vivo deposition and hypoglycaemic activity after delivery to rat lungs. J Control Release. 2009; 135(1):25-34. DOI: 10.1016/j.jconrel.2008.12.011. View

Abou Neel E, Chrzanowski W, Knowles J . Effect of increasing titanium dioxide content on bulk and surface properties of phosphate-based glasses. Acta Biomater. 2008; 4(3):523-34. DOI: 10.1016/j.actbio.2007.11.007. View

Wang Q, Huang W, Wang D, Darvell B, Day D, Rahaman M . Preparation of hollow hydroxyapatite microspheres. J Mater Sci Mater Med. 2006; 17(7):641-6. DOI: 10.1007/s10856-006-9227-5. View

Dhawan S, Singla A . Nifedipine loaded chitosan microspheres prepared by emulsification phase-separation. Biotech Histochem. 2004; 78(5):243-54. View

Xia Y, Ribeiro P, Pack D . Controlled protein release from monodisperse biodegradable double-wall microspheres of controllable shell thickness. J Control Release. 2013; 172(3):707-14. PMC: 3858475. DOI: 10.1016/j.jconrel.2013.08.009. View

10.

Komlev V, Barinov S, Koplik E . A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release. Biomaterials. 2002; 23(16):3449-54. DOI: 10.1016/s0142-9612(02)00049-2. View

11.

Athanasiou K, Agrawal C, Barber F, Burkhart S . Orthopaedic applications for PLA-PGA biodegradable polymers. Arthroscopy. 1998; 14(7):726-37. DOI: 10.1016/s0749-8063(98)70099-4. View

12.

Oh Y, Lee J, Seo J, Rhim T, Kim S, Yoon H . Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model. J Control Release. 2010; 150(1):56-62. DOI: 10.1016/j.jconrel.2010.11.001. View

13.

Tao Y, Zhang H, Hu Y, Wan S, Su Z . Preparation of Chitosan and Water-Soluble Chitosan Microspheres via Spray-Drying Method to Lower Blood Lipids in Rats Fed with High-Fat Diets. Int J Mol Sci. 2013; 14(2):4174-84. PMC: 3588093. DOI: 10.3390/ijms14024174. View

14.

Nagai N, Kumasaka N, Kawashima T, Kaji H, Nishizawa M, Abe T . Preparation and characterization of collagen microspheres for sustained release of VEGF. J Mater Sci Mater Med. 2010; 21(6):1891-8. DOI: 10.1007/s10856-010-4054-0. View

15.

Paul W, Sharma C . Development of porous spherical hydroxyapatite granules: application towards protein delivery. J Mater Sci Mater Med. 2004; 10(7):383-8. DOI: 10.1023/a:1008918412198. View

16.

Chung S, Gamcsik M, King M . Novel scaffold design with multi-grooved PLA fibers. Biomed Mater. 2011; 6(4):045001. DOI: 10.1088/1748-6041/6/4/045001. View

17.

Chan L, Lee H, Heng P . Production of alginate microspheres by internal gelation using an emulsification method. Int J Pharm. 2002; 242(1-2):259-62. DOI: 10.1016/s0378-5173(02)00170-9. View

18.

Abou Neel E, Knowles J . Physical and biocompatibility studies of novel titanium dioxide doped phosphate-based glasses for bone tissue engineering applications. J Mater Sci Mater Med. 2007; 19(1):377-86. DOI: 10.1007/s10856-007-3079-5. View

19.

Bergquist N, Holubar K, Diaz G, BEUTNER E . The manufacture of protein microspheres by suspension polymerization. Int Arch Allergy Appl Immunol. 1972; 43(5):791-9. DOI: 10.1159/000230895. View

20.

Lakhkar N, Park J, Mordan N, Salih V, Wall I, Kim H . Titanium phosphate glass microspheres for bone tissue engineering. Acta Biomater. 2012; 8(11):4181-90. DOI: 10.1016/j.actbio.2012.07.023. View