Pathophysiological Aspects of Transferrin-A Potential Nano-based Drug Delivery Signaling Molecule in Therapeutic Target for Varied Diseases

Overview

Journal Front Pharmacol

Date 2024 Mar 19

PMID 38500764

Authors

Chang Li

Liya Zhou

Xunzhe Yin

Affiliations

Soon will be listed here.

Abstract

Transferrin (Tf), widely known for its role as an iron-binding protein, exemplifies multitasking in biological processes. The role of Tf in iron metabolism involves both the uptake of iron from Tf by various cells, as well as the endocytosis mediated by the complex of Tf and the transferrin receptor (TfR). The direct conjugation of the therapeutic compound and immunotoxin studies using Tf peptide or anti-Tf receptor antibodies as targeting moieties aims to prolong drug circulation time and augment efficient cellular drug uptake, diminish systemic toxicity, traverse the blood-brain barrier, restrict systemic exposure, overcome multidrug resistance, and enhance therapeutic efficacy with disease specificity. This review primarily discusses the various biological actions of Tf, as well as the development of Tf-targeted nano-based drug delivery systems. The goal is to establish the use of Tf as a disease-targeting component, accentuating the potential therapeutic applications of this protein.

References

Korkusuz H, Ulbrich K, Bihrer V, Welzel K, Chernikov V, Knobloch T . Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging. Mol Imaging. 2012; 11(4):272-9. View

Logovinsky V, Satlin A, Lai R, Swanson C, Kaplow J, Osswald G . Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective Aβ antibody. Alzheimers Res Ther. 2016; 8(1):14. PMC: 4822297. DOI: 10.1186/s13195-016-0181-2. View

Menter D, Herrmann J, Nicolson G . The role of trophic factors and autocrine/paracrine growth factors in brain metastasis. Clin Exp Metastasis. 1995; 13(2):67-88. DOI: 10.1007/BF00133612. View

Cimini A, Mei S, Benedetti E, Laurenti G, Koutris I, Cinque B . Distinct cellular responses induced by saporin and a transferrin-saporin conjugate in two different human glioblastoma cell lines. J Cell Physiol. 2011; 227(3):939-51. DOI: 10.1002/jcp.22805. View

Kawabata H, Germain R, Vuong P, Nakamaki T, Said J, Koeffler H . Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem. 2000; 275(22):16618-25. DOI: 10.1074/jbc.M908846199. View

Metz-Boutigue M, Jolles J, Mazurier J, Schoentgen F, Legrand D, SPIK G . Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins. Eur J Biochem. 1984; 145(3):659-76. DOI: 10.1111/j.1432-1033.1984.tb08607.x. View

Weinzimer S, Gibson T, Collett-Solberg P, Khare A, Liu B, Cohen P . Transferrin is an insulin-like growth factor-binding protein-3 binding protein. J Clin Endocrinol Metab. 2001; 86(4):1806-13. DOI: 10.1210/jcem.86.4.7380. View

Anthony D, Sibson N, McAteer M, Davis B, Choudhury R . Detection of brain pathology by magnetic resonance imaging of iron oxide micro-particles. Methods Mol Biol. 2010; 686:213-27. DOI: 10.1007/978-1-60761-938-3_9. View

Lin L, Pantapalangkoor P, Tan B, Bruhn K, Ho T, Nielsen T . Transferrin iron starvation therapy for lethal bacterial and fungal infections. J Infect Dis. 2014; 210(2):254-64. PMC: 4092247. DOI: 10.1093/infdis/jiu049. View

10.

Pang Z, Gao H, Yu Y, Guo L, Chen J, Pan S . Enhanced intracellular delivery and chemotherapy for glioma rats by transferrin-conjugated biodegradable polymersomes loaded with doxorubicin. Bioconjug Chem. 2011; 22(6):1171-80. DOI: 10.1021/bc200062q. View

11.

Weaver M, Laske D . Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas. J Neurooncol. 2003; 65(1):3-13. DOI: 10.1023/a:1026246500788. View

12.

Karagiannis T, Lobachevsky P, Leung B, White J, Martin R . Receptor-mediated DNA-targeted photoimmunotherapy. Cancer Res. 2006; 66(21):10548-52. DOI: 10.1158/0008-5472.CAN-06-1853. View

13.

Shah N, Chaudhari K, Dantuluri P, Murthy R, Das S . Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic((R))P85, an in vitro cell line and in vivo biodistribution studies on rat model. J Drug Target. 2009; 17(7):533-42. DOI: 10.1080/10611860903046628. View

14.

Vyas S, Sihorkar V . Endogenous carriers and ligands in non-immunogenic site-specific drug delivery. Adv Drug Deliv Rev. 2000; 43(2-3):101-64. DOI: 10.1016/s0169-409x(00)00067-3. View

15.

Li J, Zhang Z, Zhang B, Yan X, Fan K . Transferrin receptor 1 targeted nanomedicine for brain tumor therapy. Biomater Sci. 2023; 11(10):3394-3413. DOI: 10.1039/d2bm02152h. View

16.

Lakkadwala S, Dos Santos Rodrigues B, Sun C, Singh J . Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma. J Control Release. 2019; 307:247-260. PMC: 6732022. DOI: 10.1016/j.jconrel.2019.06.033. View

17.

Rabiei M, Kashanian S, Samavati S, Jamasb S, McInnes S . Active Targeting Towards and Inside the Brain based on Nanoparticles: A Review. Curr Pharm Biotechnol. 2019; 21(5):374-383. DOI: 10.2174/1389201020666191203094057. View

18.

Nam J, Park S, Kim T, Jang J, Choi C, Jang M . Encapsulation of paclitaxel into lauric acid-O-carboxymethyl chitosan-transferrin micelles for hydrophobic drug delivery and site-specific targeted delivery. Int J Pharm. 2013; 457(1):124-35. DOI: 10.1016/j.ijpharm.2013.09.021. View

19.

Conrad M, Friedmann Angeli J, Vandenabeele P, Stockwell B . Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 2016; 15(5):348-66. PMC: 6531857. DOI: 10.1038/nrd.2015.6. View

20.

Papachristodoulou A, Signorell R, Werner B, Brambilla D, Luciani P, Cavusoglu M . Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes. J Control Release. 2018; 295:130-139. DOI: 10.1016/j.jconrel.2018.12.009. View