Identifying the Favored Mutation in a Positive Selective Sweep

Overview

Journal Nat Methods

Specialties Biomedical Engineering
Pathology

Date 2018 Feb 20

PMID 29457793

Citations 39

Authors

Ali Akbari

Joseph J Vitti

Arya Iranmehr

Mehrdad Bakhtiari

Pardis C Sabeti

Siavash Mirarab

Vineet Bafna

Affiliations

Soon will be listed here.

Abstract

Most approaches that capture signatures of selective sweeps in population genomics data do not identify the specific mutation favored by selection. We present iSAFE (for "integrated selection of allele favored by evolution"), a method that enables researchers to accurately pinpoint the favored mutation in a large region (∼5 Mbp) by using a statistic derived solely from population genetics signals. iSAFE does not require knowledge of demography, the phenotype under selection, or functional annotations of mutations.

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