MAIT Cells and Microbial Immunity

Overview

Journal Immunol Cell Biol

Publisher Wiley

Specialties Allergy & Immunology
Cell Biology

Date 2018 Feb 17

PMID 29451704

Citations 47

Authors

Erin W Meermeier

Melanie J Harriff

Elham Karamooz

David M Lewinsohn

Affiliations

Soon will be listed here.

Abstract

Mucosal-associated invariant T (MAIT) cells, the most abundant T-cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T-cell receptor (TCR) triggering as well as cytokine stimulation in response to a host of microbial products. In this review, we specifically discuss MAIT cell responses to bacterial and fungal infections, with a focus on responses that are both MR1-dependent and -independent, the evidence for diversity in MAIT TCR usage in response to discrete microbial products, protective immunity induced by MAIT cells, and MAIT cell antimicrobial functions in the context of these infections.

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References

Shaler C, Choi J, Rudak P, Memarnejadian A, Szabo P, Tun-Abraham M . MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced.... PLoS Biol. 2017; 15(6):e2001930. PMC: 5478099. DOI: 10.1371/journal.pbio.2001930. View

Sharma P, Wong E, Napier R, Bishai W, Ndungu T, Kasprowicz V . High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells. Immunology. 2015; 145(3):443-53. PMC: 4479542. DOI: 10.1111/imm.12461. View

Lepore M, Kalinichenko A, Calogero S, Kumar P, Paleja B, Schmaler M . Functionally diverse human T cells recognize non-microbial antigens presented by MR1. Elife. 2017; 6. PMC: 5459576. DOI: 10.7554/eLife.24476. View

Georgel P, Radosavljevic M, Macquin C, Bahram S . The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice. Mol Immunol. 2010; 48(5):769-75. DOI: 10.1016/j.molimm.2010.12.002. View

Haga K, Chiba A, Shibuya T, Osada T, Ishikawa D, Kodani T . MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis. J Gastroenterol Hepatol. 2015; 31(5):965-72. DOI: 10.1111/jgh.13242. View

Gold M, Cerri S, Smyk-Pearson S, Cansler M, Vogt T, Delepine J . Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 2010; 8(6):e1000407. PMC: 2893946. DOI: 10.1371/journal.pbio.1000407. View

Liuzzi A, Kift-Morgan A, Lopez-Anton M, Friberg I, Zhang J, Brook A . Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling. J Immunol. 2016; 197(6):2195-207. PMC: 5009878. DOI: 10.4049/jimmunol.1600990. View

Corbett A, Eckle S, Birkinshaw R, Liu L, Patel O, Mahony J . T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature. 2014; 509(7500):361-5. DOI: 10.1038/nature13160. View

Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K . A highly conserved major histocompatibility complex class I-related gene in mammals. Biochem Biophys Res Commun. 1997; 238(3):697-702. DOI: 10.1006/bbrc.1997.7379. View

10.

McWilliam H, Eckle S, Theodossis A, Liu L, Chen Z, Wubben J . The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1. Nat Immunol. 2016; 17(5):531-7. DOI: 10.1038/ni.3416. View

11.

Huang S, Gilfillan S, Kim S, Thompson B, Wang X, Sant A . MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells. J Exp Med. 2008; 205(5):1201-11. PMC: 2373850. DOI: 10.1084/jem.20072579. View

12.

Tang X, Jo J, Tan A, Sandalova E, Chia A, Tan K . IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol. 2013; 190(7):3142-52. DOI: 10.4049/jimmunol.1203218. View

13.

Meierovics A, Cowley S . MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection. J Exp Med. 2016; 213(12):2793-2809. PMC: 5110023. DOI: 10.1084/jem.20160637. View

14.

Le Bourhis L, Martin E, Peguillet I, Guihot A, Froux N, Core M . Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol. 2010; 11(8):701-8. DOI: 10.1038/ni.1890. View

15.

Jiang J, Chen X, An H, Yang B, Zhang F, Cheng X . Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling. Sci Rep. 2016; 6:32320. PMC: 5009363. DOI: 10.1038/srep32320. View

16.

Chua W, Truscott S, Eickhoff C, Blazevic A, Hoft D, Hansen T . Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection. Infect Immun. 2012; 80(9):3256-67. PMC: 3418730. DOI: 10.1128/IAI.00279-12. View

17.

Porcelli S, Yockey C, Brenner M, Balk S . Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J Exp Med. 1993; 178(1):1-16. PMC: 2191070. DOI: 10.1084/jem.178.1.1. View

18.

Hayashi E, Chiba A, Tada K, Haga K, Kitagaichi M, Nakajima S . Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis. J Rheumatol. 2016; 43(9):1695-703. DOI: 10.3899/jrheum.151133. View

19.

Leeansyah E, Loh L, Nixon D, Sandberg J . Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development. Nat Commun. 2014; 5:3143. PMC: 3916833. DOI: 10.1038/ncomms4143. View

20.

Reantragoon R, Corbett A, Sakala I, Gherardin N, Furness J, Chen Z . Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. J Exp Med. 2013; 210(11):2305-20. PMC: 3804952. DOI: 10.1084/jem.20130958. View