Quantitative Variations of the C3b/C4b Receptor (CR1) in Human Erythrocytes Are Controlled by Genes Within the Regulator of Complement Activation (RCA) Gene Cluster

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1986 Oct 1

PMID 2944984

Citations 18

Authors

S Rodriguez de Cordoba

P Rubinstein

Affiliations

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Abstract

The genetic relationships of quantitative and structural variations of the C3b/C4b receptor (CR1) in human erythrocytes have been analyzed in informative families. Our results demonstrate the existence of multiple discrete quantitative variations of CR1 controlled by a locus, C3bRQ, closely linked to the CR1 structural locus, C3bR. Since the amounts of CR1 produced by each C3bR allele are shown to be independently regulated, we propose that a cis-acting genetic mechanism controls the level of expression of the C3bR alleles, and that this quantitative control plays a major, if not the sole, role in determining the total amounts of CR1 on normal human erythrocytes.

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