Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method

Overview

Journal Drug Metab Dispos

Specialty Pharmacology

Date 2018 Feb 16

PMID 29444903

Citations 10

Authors

Yuan Wei

Li Yang

Xiaoyan Zhang

Danjuan Sui

Changsuo Wang

Kai Wang

Mangting Shan

Dayong Guo

Hongyu Wang

Affiliations

Soon will be listed here.

Abstract

CYP2C11 is involved in the metabolism of many drugs in rats. To assess the roles of CYP2C11 in physiology and drug metabolism, a -null rat model was generated using the clustered

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