Capillary Rarefaction and Altered Renal Development: the Imbalance Between Pro- and Anti-angiogenic Factors in Response to Angiotensin II Inhibition in the Developing Rat Kidney

Overview

Journal J Mol Histol

Specialty Biochemistry

Date 2018 Feb 15

PMID 29442209

Citations 10

Authors

Kee Hwan Yoo

Hyung Eun Yim

Eun Soo Bae

Young Sook Hong

Affiliations

Soon will be listed here.

Abstract

Proper and timely assembly of the kidney vasculature with their respective nephrons is crucial during normal kidney development. In this study, we investigated the effects of enalapril (angiotensin-converting enzyme inhibitor) on angiogenesis-related gene expression and microvascular endothelium related to glomeular and tubular changes in the neonatal rat kidney. Enalapril-treated rats had higher tubular injury scores and lower glomerular maturity grades than those of untreated rats. In the enalapril-treated group, intrarenal angiopoietin-2, Tie-2, and thrombospondin-1 protein expression increased, whereas intrarenal angiopoietin-1 protein expression decreased. JG12-positive glomerular and peritubular capillary staining was reduced in the enalapril-treated rat kidney. The number of JG12-positive capillary endothelial cells was directly correlated with glomerular maturation grade and was inversely related with the tubular injury. Our findings suggest the imbalance between pro- and anti-angiogenic factors may be implicated in the loss of capillaries in associated with impaired nephrogenesis after angiotensin II blockade in the developing rat kidney.

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