Anti-inflammatory Effect of Oligostilbenoids from Vitis Heyneana in LPS-stimulated RAW 264.7 Macrophages Via Suppressing the NF-κB Activation

Overview

Journal Chem Cent J

Publisher Biomed Central

Specialty Chemistry

Date 2018 Feb 15

PMID 29442202

Citations 5

Authors

Do Thi Ha

Phung Thanh Long

Tran Thi Hien

Dao Trong Tuan

Nguyen Thi Thuy An

Nguyen Minh Khoi

Ha Van Oanh

Tran Manh Hung

Affiliations

Soon will be listed here.

Abstract

Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property.

Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-κB activation.

Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-κB activation in RAW 264.7 cells.

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