Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis

Overview

Journal Sci Rep

Specialty Science

Date 2018 Feb 15

PMID 29440650

Citations 48

Authors

Iryna Saranchova

Jeffrey Han

Rysa Zaman

Hitesh Arora

Hui Huang

Franz Fenninger

Kyung Bok Choi

Lonna Munro

Cheryl G Pfeifer

Ian Welch

Fumio Takei

Wilfred A Jefferies

Affiliations

Soon will be listed here.

Abstract

Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs) and resulting metastasis to distal organs. Our data support the model that IL-33 dependent tumour-infiltrating ILC2s are mobilized from the lungs and other tissues through chemoattraction to enter tumours, and subsequently mediate tumour immune-surveillance by cooperating with dendritic cells to promote adaptive cytolytic T cell responses. We conclude that ILC2s play a fundamental, yet hitherto undescribed role in enhancing anti-cancer immunity and controlling tumour metastasis.

Citing Articles

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