Loss of Function of a Rice TPR-domain RNA-binding Protein Confers Broad-spectrum Disease Resistance

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2018 Feb 13

PMID 29432165

Citations 88

Authors

Xiaogang Zhou

Haicheng Liao

Mawsheng Chern

Junjie Yin

Yufei Chen

Jianping Wang

Xiaobo Zhu

Zhixiong Chen

Can Yuan

Wen Zhao

Jing Wang

Weitao Li

Min He

Bingtian Ma

Jichun Wang

Peng Qin

Weilan Chen

Yuping Wang

Jiali Liu

Yangwen Qian

Wenming Wang

Xianjun Wu

Ping Li

Lihuang Zhu

Shigui Li

Pamela C Ronald

Xuewei Chen

Affiliations

Soon will be listed here.

Abstract

Crops carrying broad-spectrum resistance loci provide an effective strategy for controlling infectious disease because these loci typically confer resistance to diverse races of a pathogen or even multiple species of pathogens. Despite their importance, only a few crop broad-spectrum resistance loci have been reported. Here, we report the identification and characterization of the rice (broad-spectrum resistance Kitaake-1) mutant, which confers broad-spectrum resistance against and pv with no major penalty on key agronomic traits. Map-based cloning reveals that encodes a tetratricopeptide repeats (TPRs)-containing protein, which binds to mRNAs of multiple () genes and promotes their turnover. Loss of function of the gene leads to accumulation of mRNAs in the mutant. Furthermore, overexpression of in wild-type rice TP309 confers resistance to , supporting the role of Our discovery of the allele constitutes a significant conceptual advancement and provides a valuable tool for breeding broad-spectrum resistant rice.

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