UPR Regulation and Output: a Stress Response Mediated by Mitochondrial-nuclear Communication

Overview

Journal Cell Res

Specialty Cell Biology

Date 2018 Feb 10

PMID 29424373

Citations 231

Authors

Andrew Melber

Cole M Haynes

Affiliations

Soon will be listed here.

Abstract

The mitochondrial network is not only required for the production of energy, essential cofactors and amino acids, but also serves as a signaling hub for innate immune and apoptotic pathways. Multiple mechanisms have evolved to identify and combat mitochondrial dysfunction to maintain the health of the organism. One such pathway is the mitochondrial unfolded protein response (UPR), which is regulated by the mitochondrial import efficiency of the transcription factor ATFS-1 in C. elegans and potentially orthologous transcription factors in mammals (ATF4, ATF5, CHOP). Upon mitochondrial dysfunction, import of ATFS-1 into mitochondria is reduced, allowing it to be trafficked to the nucleus where it promotes the expression of genes that promote survival and recovery of the mitochondrial network. Here, we discuss recent findings underlying UPR signal transduction and how this adaptive transcriptional response may interact with other mitochondrial stress response pathways.

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