Adipocytokines in Obese Ghanaian Subjects with or Without Type 2 Diabetes

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2018 Feb 10

PMID 29422086

Citations 3

Authors

Yussif Adams

Emmanuel Kwaku Ofori

Henry Asare-Anane

Seth D Amanquah

Grace Korkor Ababio

Emmanuel Abendau

Richard Nabia

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes and to find out the extent to which their levels are influenced by underlying disorders.

Results: Obese subjects with type 2 diabetes had lower leptin but higher hsCRP levels compared with obese non-diabetic controls. There were negative correlations within the control group for glucose vs % muscle mass (r = - 0.378, p = 0.016), leptin vs % muscle mass (r = - 0.555, p = 0.001) and within the obese diabetic group for leptin vs % muscle mass (r = - 0.602, p = 0.001). Obese persons without diabetes were about three times more likely to have higher leptin levels compared with their obese diabetic counterparts (Odds ratio = 3.315, p < 0.001). Obese females independently had a tenfold increase in leptin levels compared with obese males.

Citing Articles

The effect of hydrophilic statins on adiponectin, leptin, visfatin, and vaspin levels in streptozocin-induced diabetic rats.

Kaya H, Demirtas B Naunyn Schmiedebergs Arch Pharmacol. 2024; .

PMID: 39382680 DOI: 10.1007/s00210-024-03517-6.

Impact of blood perilipin A levels on obesity and metabolic health.

Ofori E, Letsu B, Amponsah S, Ahenkorah J, Crabbe S, Kwao-Zigah G BMC Res Notes. 2022; 15(1):367.

PMID: 36503541 PMC: 9743615. DOI: 10.1186/s13104-022-06261-3.

Leptin concentrations in type 2 diabetes and non-diabetes Nigerian-Africans.

Onyemelukwe O, Ogoina D, Onyemelukwe G Am J Cardiovasc Dis. 2020; 10(4):444-454.

PMID: 33224595 PMC: 7675163.

References

Mohammadzadeh G, Zarghami N . Serum leptin level is reduced in non-obese subjects with type 2 diabetes. Int J Endocrinol Metab. 2013; 11(1):3-10. PMC: 3693653. DOI: 10.5812/ijem.6535. View

Benkeser R, Biritwum R, HILL A . Prevalence of overweight and obesity and perception of healthy and desirable body size in urban, Ghanaian women. Ghana Med J. 2012; 46(2):66-75. PMC: 3426384. View

Schuster D . Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation. Diabetes Metab Syndr Obes. 2011; 3:253-62. PMC: 3047970. DOI: 10.2147/dmsott.s7354. View

Zeman M, Jirak R, Jachymova M, Vecka M, Tvrzicka E, Zak A . Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. Neuro Endocrinol Lett. 2009; 30(3):387-95. View

Amoah A, Owusu S, Adjei S . Diabetes in Ghana: a community based prevalence study in Greater Accra. Diabetes Res Clin Pract. 2002; 56(3):197-205. DOI: 10.1016/s0168-8227(01)00374-6. View

Jung C, Kim B, Kim C, Kang S, Jung S, Mok J . Association of serum adipocytokine levels with cardiac autonomic neuropathy in type 2 diabetic patients. Cardiovasc Diabetol. 2012; 11:24. PMC: 3353195. DOI: 10.1186/1475-2840-11-24. View

Biritwum R, Gyapong J, Mensah G . The epidemiology of obesity in ghana. Ghana Med J. 2007; 39(3):82-5. PMC: 1790818. View

Cnop M, Landchild M, Vidal J, Havel P, Knowles N, Carr D . The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. Diabetes. 2002; 51(4):1005-15. DOI: 10.2337/diabetes.51.4.1005. View

Sweeney G . Leptin signalling. Cell Signal. 2002; 14(8):655-63. DOI: 10.1016/s0898-6568(02)00006-2. View

10.

Pandey R, Kumar N, Paroha S, Prasad R, Yadav M, Jain S . Impact of obesity and diabetes on arthritis: An update. Health (Irvine Calif). 2019; 5(1):143-156. PMC: 6309558. DOI: 10.4236/health.2013.51019. View

11.

Abu-Hasheesh M, Abu-Samak M, Al-Matubsi H, Jaradeh M, Jarrah S, Khuzaie R . Association of parental history of type 2 diabetes mellitus with leptin levels in Jordanian male youths. Saudi Med J. 2010; 31(8):882-6. View

12.

Wei M, Stern M, Haffner S . Serum leptin levels in Mexican Americans and non-Hispanic whites: association with body mass index and cigarette smoking. Ann Epidemiol. 1997; 7(2):81-6. DOI: 10.1016/s1047-2797(96)00114-7. View

13.

Freeman D, Norrie J, Caslake M, Gaw A, Ford I, Lowe G . C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes. 2002; 51(5):1596-600. DOI: 10.2337/diabetes.51.5.1596. View

14.

McNeely M, Boyko E, Weigle D, Shofer J, Chessler S, Leonnetti D . Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care. 1999; 22(1):65-70. DOI: 10.2337/diacare.22.1.65. View

15.

Montague C, ORahilly S . The perils of portliness: causes and consequences of visceral adiposity. Diabetes. 2000; 49(6):883-8. DOI: 10.2337/diabetes.49.6.883. View

16.

Santos A, Lopes C, Guimaraes J, Barros H . Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. Int J Obes (Lond). 2005; 29(12):1452-6. DOI: 10.1038/sj.ijo.0803035. View

17.

Jiao P, Xu H . Adipose inflammation: cause or consequence of obesity-related insulin resistance. Diabetes Metab Syndr Obes. 2011; 1:25-31. PMC: 3052712. DOI: 10.2147/dmso.s4180. View

18.

Martin S, Qasim A, Reilly M . Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol. 2008; 52(15):1201-10. PMC: 4556270. DOI: 10.1016/j.jacc.2008.05.060. View

19.

Pickup J . Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004; 27(3):813-23. DOI: 10.2337/diacare.27.3.813. View

20.

Singh M, Bedi U, Singh P, Arora R, Khosla S . Leptin and the clinical cardiovascular risk. Int J Cardiol. 2009; 140(3):266-71. DOI: 10.1016/j.ijcard.2009.07.019. View