Impact of Blood Perilipin A Levels on Obesity and Metabolic Health

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2022 Dec 12

PMID 36503541

Authors

Emmanuel K Ofori

Bright Selorm Letsu

Seth K Amponsah

John Ahenkorah

Sandra Crabbe

Genevieve Kwao-Zigah

Sylvester Y Oppong

Patrick Diaba-Nuhoho

Seth D Amanquah

Affiliations

Soon will be listed here.

Abstract

Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health.

Results: The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = - 0.32, - 0.37, - 0.40, - 0.45, - 0.33 and - 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35-11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.

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References

Krahmer N, Farese Jr R, Walther T . Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013; 5(7):973-83. PMC: 3721468. DOI: 10.1002/emmm.201100671. View

Sztalryd C, Brasaemle D . The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis. Biochim Biophys Acta Mol Cell Biol Lipids. 2017; 1862(10 Pt B):1221-1232. PMC: 5595658. DOI: 10.1016/j.bbalip.2017.07.009. View

Mottagui-Tabar S, Ryden M, Lofgren P, Faulds G, Hoffstedt J, Brookes A . Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Diabetologia. 2003; 46(6):789-97. DOI: 10.1007/s00125-003-1112-x. View

Arner P, Langin D . Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance. Trends Endocrinol Metab. 2014; 25(5):255-62. DOI: 10.1016/j.tem.2014.03.002. View

Forouhi N, Wareham N . Epidemiology of diabetes. Medicine (Abingdon). 2015; 42(12):698-702. PMC: 4282306. DOI: 10.1016/j.mpmed.2014.09.007. View

Andersson D, Arner E, Hogling D, Ryden M, Arner P . Abdominal subcutaneous adipose tissue cellularity in men and women. Int J Obes (Lond). 2017; 41(10):1564-1569. DOI: 10.1038/ijo.2017.148. View

Pillon N, Loos R, Marshall S, Zierath J . Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. Cell. 2021; 184(6):1530-1544. PMC: 9191863. DOI: 10.1016/j.cell.2021.02.012. View

Conte M, Santoro A, Collura S, Martucci M, Battista G, Bazzocchi A . Circulating perilipin 2 levels are associated with fat mass, inflammatory and metabolic markers and are higher in women than men. Aging (Albany NY). 2021; 13(6):7931-7942. PMC: 8034884. DOI: 10.18632/aging.202840. View

Luglio H, Sulistyoningrum D, Susilowati R . The role of genes involved in lipolysis on weight loss program in overweight and obese individuals. J Clin Biochem Nutr. 2015; 57(2):91-7. PMC: 4566022. DOI: 10.3164/jcbn.14-117. View

10.

Smith C, Ordovas J . Update on perilipin polymorphisms and obesity. Nutr Rev. 2012; 70(10):611-21. PMC: 4356110. DOI: 10.1111/j.1753-4887.2012.00515.x. View

11.

Welte M, Gould A . Lipid droplet functions beyond energy storage. Biochim Biophys Acta Mol Cell Biol Lipids. 2017; 1862(10 Pt B):1260-1272. PMC: 5595650. DOI: 10.1016/j.bbalip.2017.07.006. View

12.

Mitchell A, Cole J, McArdle P, Cheng Y, Ryan K, Sparks M . Obesity increases risk of ischemic stroke in young adults. Stroke. 2015; 46(6):1690-2. PMC: 4458137. DOI: 10.1161/STROKEAHA.115.008940. View

13.

Bickel P, Tansey J, Welte M . PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta. 2009; 1791(6):419-40. PMC: 2782626. DOI: 10.1016/j.bbalip.2009.04.002. View

14.

Elagizi A, Kachur S, Carbone S, Lavie C, Blair S . A Review of Obesity, Physical Activity, and Cardiovascular Disease. Curr Obes Rep. 2020; 9(4):571-581. DOI: 10.1007/s13679-020-00403-z. View

15.

Li S, Zhao J, Luan J, Langenberg C, Luben R, Khaw K . Genetic predisposition to obesity leads to increased risk of type 2 diabetes. Diabetologia. 2011; 54(4):776-82. PMC: 3052481. DOI: 10.1007/s00125-011-2044-5. View

16.

Kern P, Di Gregorio G, Lu T, Rassouli N, Ranganathan G . Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab. 2004; 89(3):1352-8. DOI: 10.1210/jc.2003-031388. View

17.

Itabe H, Yamaguchi T, Nimura S, Sasabe N . Perilipins: a diversity of intracellular lipid droplet proteins. Lipids Health Dis. 2017; 16(1):83. PMC: 5410086. DOI: 10.1186/s12944-017-0473-y. View

18.

Asare-Anane H, Ofori E, Agyemang Y, Oppong S, Tagoe E, Bani S . Obesity and Testosterone Levels in Ghanaian Men With Type 2 Diabetes. Clin Diabetes. 2015; 32(2):61-5. PMC: 4485250. DOI: 10.2337/diaclin.32.2.61. View

19.

Neeland I, Ayers C, Rohatgi A, Turer A, Berry J, Das S . Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults. Obesity (Silver Spring). 2013; 21(9):E439-47. PMC: 3751977. DOI: 10.1002/oby.20135. View

20.

Westphal S . Obesity, abdominal obesity, and insulin resistance. Clin Cornerstone. 2008; 9(1):23-29. DOI: 10.1016/s1098-3597(08)60025-3. View