Thyroid Autoimmunity: An Interplay of Factors

Overview

Journal Vitam Horm

Specialties Endocrinology
Nutritional Sciences

Date 2018 Feb 7

PMID 29407432

Citations 13

Authors

Stephen J Merrill

Sarah B Minucci

Affiliations

Soon will be listed here.

Abstract

Aims: To describe the many factors at play in thyroid autoimmunity and how they interact.

Conclusion: Thyroid autoimmunity is the result of an interplay of factors, with adipokines produced by WAT and vitamin D providing immune modulating signals external to the thyroid, while thyrocyte innate responses to environmental conditions provide the necessary adjuvant signal. Shaping the response to be reactive to particular self-antigens and likelihood of a response are due to genetics and molecular mimics.

Citing Articles

Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis.

Rostami R, Beiranvand A, Nourooz-Zadeh S, Rostami M, Mohammadi A, Nourooz-Zadeh J Int J Endocrinol Metab. 2025; 22(2):e145599.

PMID: 40071251 PMC: 11892519. DOI: 10.5812/ijem-145599.

The Influence of Concurrent Autoimmune Thyroiditis on the Cardiometabolic Consequences of Cabergoline in Postmenopausal Women.

Krysiak R, Basiak M, Szkrobka W, Okopien B Metabolites. 2025; 15(1).

PMID: 39852352 PMC: 11767027. DOI: 10.3390/metabo15010009.

Autoimmune Thyroiditis Mitigates the Effect of Metformin on Plasma Prolactin Concentration in Men with Drug-Induced Hyperprolactinemia.

Krysiak R, Basiak M, Szkrobka W, Okopien B Pharmaceuticals (Basel). 2024; 17(8).

PMID: 39204081 PMC: 11357093. DOI: 10.3390/ph17080976.

Global scientific trends on thyroid disease in early 21st century: a bibliometric and visualized analysis.

Song M, Sun W, Liu Q, Wang Z, Zhang H Front Endocrinol (Lausanne). 2024; 14:1306232.

PMID: 38298184 PMC: 10829784. DOI: 10.3389/fendo.2023.1306232.

Sexual Function and Depressive Symptoms in Young Women with Euthyroid Hashimoto's Thyroiditis Receiving Vitamin D, Selenomethionine and Myo-Inositol: A Pilot Study.

Krysiak R, Kowalcze K, Szkrobka W, Okopien B Nutrients. 2023; 15(12).

PMID: 37375719 PMC: 10304218. DOI: 10.3390/nu15122815.