» Articles » PMID: 29404401

MiRNA-convergent Gene Fusions

Overview
Journal Mol Cell Oncol
Specialty Oncology
Date 2018 Feb 7
PMID 29404401
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

In a recent study published in Nature Communications, we showed that intron-encoded microRNA genes (miRNA) are frequent partners of fusion genes in the cancer genome. Analyzed from a functional rather than structural perspective, these rearrangements represent a new class of fusions we called "miRNA-convergent fusions".

Citing Articles

Cancer fusion transcripts with human non-coding RNAs.

Mohammad T, Zolotovskaia M, Suntsova M, Buzdin A Front Oncol. 2024; 14:1415801.

PMID: 38919532 PMC: 11196610. DOI: 10.3389/fonc.2024.1415801.


Exploring the Relationship between Fusion Genes and MicroRNAs in Cancer.

Panicker S, Chengizkhan G, Gor R, Ramachandran I, Ramalingam S Cells. 2023; 12(20).

PMID: 37887311 PMC: 10605240. DOI: 10.3390/cells12202467.


Non-coding RNAs in cancers with chromosomal rearrangements: the signatures, causes, functions and implications.

Han C, Sun L, Wang W, Sun Y, Chen Y J Mol Cell Biol. 2019; 11(10):886-898.

PMID: 31361891 PMC: 6884712. DOI: 10.1093/jmcb/mjz080.

References
1.
Feldman A, Dogan A, Smith D, Law M, Ansell S, Johnson S . Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood. 2010; 117(3):915-9. PMC: 3035081. DOI: 10.1182/blood-2010-08-303305. View

2.
Calin G, Sevignani C, Dumitru C, Hyslop T, Noch E, Yendamuri S . Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004; 101(9):2999-3004. PMC: 365734. DOI: 10.1073/pnas.0307323101. View

3.
Persson H, Sokilde R, Hakkinen J, Pirona A, Vallon-Christersson J, Kvist A . Frequent miRNA-convergent fusion gene events in breast cancer. Nat Commun. 2017; 8(1):788. PMC: 5629207. DOI: 10.1038/s41467-017-01176-1. View

4.
Blum A, Venkitachalam S, Guo Y, Kieber-Emmons A, Ravi L, Chandar A . RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas. Cancer Res. 2016; 76(19):5628-5633. PMC: 5050127. DOI: 10.1158/0008-5472.CAN-16-0979. View

5.
Tassano E, Acquila M, Tavella E, Micalizzi C, Panarello C, Morerio C . MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2010; 49(8):682-7. DOI: 10.1002/gcc.20776. View