MiRNA-convergent Gene Fusions
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In a recent study published in Nature Communications, we showed that intron-encoded microRNA genes (miRNA) are frequent partners of fusion genes in the cancer genome. Analyzed from a functional rather than structural perspective, these rearrangements represent a new class of fusions we called "miRNA-convergent fusions".
Cancer fusion transcripts with human non-coding RNAs.
Mohammad T, Zolotovskaia M, Suntsova M, Buzdin A Front Oncol. 2024; 14:1415801.
PMID: 38919532 PMC: 11196610. DOI: 10.3389/fonc.2024.1415801.
Exploring the Relationship between Fusion Genes and MicroRNAs in Cancer.
Panicker S, Chengizkhan G, Gor R, Ramachandran I, Ramalingam S Cells. 2023; 12(20).
PMID: 37887311 PMC: 10605240. DOI: 10.3390/cells12202467.
Han C, Sun L, Wang W, Sun Y, Chen Y J Mol Cell Biol. 2019; 11(10):886-898.
PMID: 31361891 PMC: 6884712. DOI: 10.1093/jmcb/mjz080.