Recent Progress in CFTR Interactome Mapping and Its Importance for Cystic Fibrosis

Overview

Journal Front Pharmacol

Date 2018 Feb 7

PMID 29403380

Citations 14

Authors

Sang Hyun Lim

Elizabeth-Ann Legere

Jamie Snider

Igor Stagljar

Affiliations

Soon will be listed here.

Abstract

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of phenotypic variance resulting from perturbations of this protein interaction network. Studying the collection of CFTR interacting proteins and the differences between the interactomes of mutant and wild type CFTR provides insight into the molecular machinery of the disease and highlights possible therapeutic targets. This mini review focuses on functional genomics and proteomics approaches used for systematic, high-throughput identification of CFTR-interacting proteins to provide comprehensive insight into CFTR regulation and function.

Citing Articles

Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector.

Romeo E, Saccoliti F, Ocello R, Andonaia A, Allegretta C, Pastorino C J Med Chem. 2025; 68(4):4596-4618.

PMID: 39928576 PMC: 11873939. DOI: 10.1021/acs.jmedchem.4c02654.

CFTR dysfunction leads to defective bacterial eradication on cystic fibrosis airways.

Wu M, Chen J Front Physiol. 2024; 15:1385661.

PMID: 38699141 PMC: 11063615. DOI: 10.3389/fphys.2024.1385661.

A Proteomic Survey of the Cystic Fibrosis Transmembrane Conductance Regulator Surfaceome.

Iazzi M, Sadeghi S, Gupta G Int J Mol Sci. 2023; 24(14).

PMID: 37511222 PMC: 10380767. DOI: 10.3390/ijms241411457.

CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells.

Ribeiro J, Bernardino R, Carrageta D, Soveral G, Calamita G, Alves M Cell Mol Life Sci. 2022; 79(12):592.

PMID: 36378343 PMC: 11803011. DOI: 10.1007/s00018-022-04619-1.

Distinct proteostasis states drive pharmacologic chaperone susceptibility for cystic fibrosis transmembrane conductance regulator misfolding mutants.

McDonald E, Sabusap C, Kim M, Plate L Mol Biol Cell. 2022; 33(7):ar62.

PMID: 35389766 PMC: 9561855. DOI: 10.1091/mbc.E21-11-0578.

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