A Proteomic Survey of the Cystic Fibrosis Transmembrane Conductance Regulator Surfaceome

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 29

PMID 37511222

Authors

Melissa Iazzi

Sara Sadeghi

Gagan D Gupta

Affiliations

Soon will be listed here.

Abstract

The aim of this review article is to collate recent contributions of proteomic studies to cystic fibrosis transmembrane conductance regulator (CFTR) biology. We summarize advances from these studies and create an accessible resource for future CFTR proteomic efforts. We focus our attention on the CFTR interaction network at the cell surface, thus generating a CFTR 'surfaceome'. We review the main findings about CFTR interactions and highlight several functional categories amongst these that could lead to the discovery of potential biomarkers and drug targets for CF.

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References

Simoes F, Ousingsawat J, Wanitchakool P, Fonseca A, Cabrita I, Benedetto R . CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6). Pflugers Arch. 2017; 470(2):305-314. DOI: 10.1007/s00424-017-2065-0. View

Valley H, Bukis K, Bell A, Cheng Y, Wong E, Jordan N . Isogenic cell models of cystic fibrosis-causing variants in natively expressing pulmonary epithelial cells. J Cyst Fibros. 2018; 18(4):476-483. DOI: 10.1016/j.jcf.2018.12.001. View

Gingras A, Abe K, Raught B . Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles. Curr Opin Chem Biol. 2018; 48:44-54. DOI: 10.1016/j.cbpa.2018.10.017. View

Arndt V, Daniel C, Nastainczyk W, Alberti S, Hohfeld J . BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell. 2005; 16(12):5891-900. PMC: 1289430. DOI: 10.1091/mbc.e05-07-0660. View

Monterisi S, Casavola V, Zaccolo M . Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling. Br J Pharmacol. 2012; 169(1):1-9. PMC: 3632233. DOI: 10.1111/bph.12017. View

Haggie P, Kim J, Lukacs G, Verkman A . Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell. 2006; 17(12):4937-45. PMC: 1679663. DOI: 10.1091/mbc.e06-08-0670. View

Bates I, Hebert B, Luo Y, Liao J, Bachir A, Kolin D . Membrane lateral diffusion and capture of CFTR within transient confinement zones. Biophys J. 2006; 91(3):1046-58. PMC: 1563763. DOI: 10.1529/biophysj.106.084830. View

Martin E, Barbieri A, Ford R, Robinson R . crystals reveal critical features of the interaction between cystic fibrosis transmembrane conductance regulator (CFTR) and the PDZ2 domain of Na/H exchange cofactor NHERF1. J Biol Chem. 2020; 295(14):4464-4476. PMC: 7135995. DOI: 10.1074/jbc.RA119.012015. View

Shanthikumar S, Neeland M, Saffery R, Ranganathan S . Gene modifiers of cystic fibrosis lung disease: A systematic review. Pediatr Pulmonol. 2019; 54(9):1356-1366. DOI: 10.1002/ppul.24366. View

10.

Gingras S, Earls L, Howell S, Smeyne R, Zakharenko S, Pelletier S . SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015; 35(29):10510-22. PMC: 4510291. DOI: 10.1523/JNEUROSCI.2056-14.2015. View

11.

Wainwright C, Elborn J, Ramsey B, Marigowda G, Huang X, Cipolli M . Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR. N Engl J Med. 2015; 373(3):220-31. PMC: 4764353. DOI: 10.1056/NEJMoa1409547. View

12.

Paranjapye A, Ruffin M, Harris A, Corvol H . Genetic variation in CFTR and modifier loci may modulate cystic fibrosis disease severity. J Cyst Fibros. 2019; 19 Suppl 1:S10-S14. PMC: 7036019. DOI: 10.1016/j.jcf.2019.11.001. View

13.

Cheng J, Wang H, Guggino W . Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL. J Biol Chem. 2003; 279(3):1892-8. DOI: 10.1074/jbc.M308640200. View

14.

Terlizzi V, Colangelo C, Marsicovetere G, DAndria M, Francalanci M, Innocenti D . Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor Therapy in Three Subjects with the Cystic Fibrosis Genotype Phe508del/Unknown and Advanced Lung Disease. Genes (Basel). 2021; 12(8). PMC: 8391133. DOI: 10.3390/genes12081178. View

15.

Yan B, Li T, Coyaud E, Laurent E, St-Germain J, Zhou Y . C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy. Autophagy. 2021; 18(4):829-840. PMC: 9037554. DOI: 10.1080/15548627.2021.1960116. View

16.

Reis C, Chen P, Srinivasan S, Aguet F, Mettlen M, Schmid S . Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis. EMBO J. 2015; 34(16):2132-46. PMC: 4557666. DOI: 10.15252/embj.201591518. View

17.

Garcia R, Falduti C, Clauzure M, Jara R, Massip-Copiz M, Aguilar M . CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells. Int J Biochem Cell Biol. 2021; 135:105976. DOI: 10.1016/j.biocel.2021.105976. View

18.

Tang B, Gee H, Lee M . The cystic fibrosis transmembrane conductance regulator's expanding SNARE interactome. Traffic. 2011; 12(4):364-71. DOI: 10.1111/j.1600-0854.2011.01161.x. View

19.

Laselva O, Bartlett C, Gunawardena T, Ouyang H, Eckford P, Moraes T . Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator. Eur Respir J. 2020; 57(6). PMC: 8209484. DOI: 10.1183/13993003.02774-2020. View

20.

Pankonien I, Quaresma M, Rodrigues C, Amaral M . CFTR, Cell Junctions and the Cytoskeleton. Int J Mol Sci. 2022; 23(5). PMC: 8910340. DOI: 10.3390/ijms23052688. View