Antispasmodic Effect of Blackcurrant (Ribes Nigrum L.) Juice and Its Potential Use As Functional Food in Gastrointestinal Disorders

Overview

Journal Med Princ Pract

Publisher Karger

Specialties General Medicine
Medical Education

Date 2018 Feb 7

PMID 29402838

Authors

Bojana Miladinovic

Suzana Brankovic

Milica Kostic

Milica Milutinovic

Nemanja Kitic

Katarina Savikin

Dusanka Kitic

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this study was to investigate the relaxative effects of blackcurrant juice on the gastrointestinal smooth muscle in vitro.

Materials And Methods: Berries of the blackcurrant cultivar Ometa were used for the preparation of the juice used. The spasmolytic activity of blackcurrant juice was tested on rat ileum isolated from male Wistar rats by monitoring its influence on spontaneous contractions, as well as contractions induced by potassium chloride (KCl), barium chloride (BaCl2), calcium chloride (CaCl2), and acetylcholine (Ach). The results are expressed as the mean ± standard deviation obtained in 6 measurements and statistical significance was determined by the Student t test, with p < 0.05 taken as significant.

Results: The blackcurrant cultivar Ometa significantly reduced the frequency and the amplitude of spontaneous contractions (57.94 ± 3.44%) and Ach-induced contractions (42.74 ± 5.36%; p < 0.05) of the isolated rat ileum. Cumulative concentrations (0.01-3 mg/mL) of the Ometa juice also reduced contractions of the isolated rat ileum stimulated by KCl (51.46 ± 6.87%), CaCl2 (57.54 ± 6.47%), and BaCl2 (58.54 ± 10.55%). The inhibitory effects of the juice were proportional to the applied concentration.

Conclusion: The antispasmodic effect of Ometa cultivar shows that common gastrointestinal disorders could be treated by the functional food.

Citing Articles

Red Currant ( L.) Fruit Waste Extract and Juice as Potential Spasmolytic Agents.

Cvetkovic M, Miladinovic B, Brankovic S, Randjelovic M, Zivanovic S, Kitic N Plants (Basel). 2025; 14(2).

PMID: 39861587 PMC: 11768213. DOI: 10.3390/plants14020234.

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