Gene Drive: Evolved and Synthetic

Overview

Journal ACS Chem Biol

Publisher American Chemical Society

Specialties Biochemistry
Biology

Date 2018 Feb 6

PMID 29400944

Citations 29

Authors

Austin Burt

Andrea Crisanti

Affiliations

Soon will be listed here.

Abstract

Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to-or indeed even if they detract from-organismal survival and reproduction. Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing endonuclease genes, B chromosomes, and transposable elements. The fact that gene drive can lead to the spread of fitness-reducing traits (including lethality and sterility) makes it an attractive process to consider exploiting to control disease vectors and other pests. There are a number of efforts to develop synthetic gene drive systems, particularly focused on the mosquito-borne diseases that continue to plague us.

Citing Articles

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A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.

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