Obstetric and Neonatal Outcome Following ICSI with Assisted Oocyte Activation by Calcium Ionophore Treatment

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2018 Feb 3

PMID 29392515

Citations 17

Authors

Ileana Mateizel

Greta Verheyen

Hilde Van de Velde

Herman Tournaye

Florence Belva

Affiliations

Soon will be listed here.

Abstract

Purpose: Calcium ionophore treatment is being used in assisted reproductive technology (ART) for cases with previous low fertilization rate or total absence of fertilization after insemination by intracytoplasmic sperm injection or when a specific indication such as globozoospermia is present. As this technique is more invasive and differs from the physiological process of fertilization, a thorough investigation of the health of the children born following this procedure is required. We intent to report the medical outcome of all children conceived following calcium ionophore treatment in our IVF center.

Methods: One-armed descriptive study is performed to report the obstetrical and neonatal outcome of children born after using calcium ionophore treatment during the intracytoplasmic sperm injection procedure in our center.

Results: A number of 237 cycles were included in this study, with 74 pregnancies reported, from which 47 children (31 singletons and 16 twin children) were born. No major malformations were detected in singletons. In twins, three children were diagnosed with major malformations. Minor malformations were present in seven singletons and in one twin.

Conclusions: In conclusion, our results regarding birth characteristics and congenital malformations are within the expected range but, although reassuring, should be interpreted with caution due to the small number of children included.

Citing Articles

Assessing the impact of calcium ionophore on pregnancy outcomes in artificial oocyte activation cycles: a 10-year update of systematic review and meta-analysis.

Zhang J, Sui Y, Xiao M, Sun X, Fu J J Assist Reprod Genet. 2024; 42(1):165-183.

PMID: 39557784 PMC: 11806169. DOI: 10.1007/s10815-024-03319-y.

High rate of detected variants in male and genes causing failed fertilization after ICSI.

Cardona Barberan A, Reddy Guggilla R, Colenbier C, Van der Velden E, Rybouchkin A, Stoop D Hum Reprod Open. 2024; 2024(4):hoae057.

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Good practice recommendations on add-ons in reproductive medicine†.

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Effect of calcium ionophore (A23187) on embryo development and its safety in PGT cycles.

Zhang J, Yao G, Zhang T, Hu J, Yang G, He J Front Endocrinol (Lausanne). 2023; 13:979248.

PMID: 36686427 PMC: 9846205. DOI: 10.3389/fendo.2022.979248.

Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles.

Chen X, Zhao H, Lv J, Dong Y, Zhao M, Sui X BMC Pregnancy Childbirth. 2022; 22(1):894.

PMID: 36460987 PMC: 9717248. DOI: 10.1186/s12884-022-05228-3.

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