Association Between Pro-inflammatory Cytokine Interleukin-33 and Periodontal Disease in the Elderly: A Retrospective Study

Overview

Journal J Indian Soc Periodontol

Date 2018 Feb 2

PMID 29386793

Citations 4

Authors

Wellington Francisco Rodrigues

Camila Botelho Miguel

Niege Silva Mendes

Carlo Jose Freire Oliveira

Carlos Ueira-Vieira

Affiliations

Soon will be listed here.

Abstract

Background: Senescence is a multifactorial process that in humans may be accompanied by inflammation and immune dysfunction in the oral cavity. Notably, periodontal disease, considered one of the most common inflammatory disorders in the oral cavity, has also been linked to the onset of other chronic inflammatory diseases common in the elderly. Thus, investigating immunity and inflammation during senescence may not only illuminate the pathophysiology of periodontal disease, but also identify new therapeutic targets.

Materials And Methods: To this end, we retrospectively and systematically reviewed studies of immune molecules associated with periodontal disease. These studies were identified in PubMed from three independent searches based on distinct sets of search terms.

Results: The data highlight the need to further investigate inflammatory molecules involved in chronic periodontal disease in the elderly, but strongly suggest that interleukin (IL)-33 is involved. Indeed, various genetic and environmental factors appear to contribute to pathogenesis via IL-33.

Conclusion: The IL-33 axis may be promising therapeutic target in elderly patients.

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References

Papathanasiou E, Teles F, Griffin T, Arguello E, Finkelman M, Hanley J . Gingival crevicular fluid levels of interferon-γ, but not interleukin-4 or -33 or thymic stromal lymphopoietin, are increased in inflamed sites in patients with periodontal disease. J Periodontal Res. 2013; 49(1):55-61. DOI: 10.1111/jre.12078. View

Beklen A, Tsaous Memet G . Interleukin-1 superfamily member, interleukin-33, in periodontal diseases. Biotech Histochem. 2013; 89(3):209-14. DOI: 10.3109/10520295.2013.832800. View

Pihlstrom B, Michalowicz B, Johnson N . Periodontal diseases. Lancet. 2005; 366(9499):1809-20. DOI: 10.1016/S0140-6736(05)67728-8. View

Van der Velden U . The onset age of periodontal destruction. J Clin Periodontol. 1991; 18(6):380-3. DOI: 10.1111/j.1600-051x.1991.tb02304.x. View

Ianova O, Medvedev D, Linkova N, Trifonov N, Diakonov M . [Molecular mechanisms of combined extremely radiofrequency and infrared therapy in various age patients with chronic parodontitis]. Adv Gerontol. 2015; 27(4):657-61. View

Malcolm J, Awang R, Oliver-Bell J, Butcher J, Campbell L, Adrados Planell A . IL-33 Exacerbates Periodontal Disease through Induction of RANKL. J Dent Res. 2015; 94(7):968-75. DOI: 10.1177/0022034515577815. View

Loesche W . Bacterial mediators in periodontal disease. Clin Infect Dis. 1993; 16 Suppl 4:S203-10. DOI: 10.1093/clinids/16.supplement_4.s203. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010; 8(5):336-41. DOI: 10.1016/j.ijsu.2010.02.007. View

Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E . Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000; 908:244-54. DOI: 10.1111/j.1749-6632.2000.tb06651.x. View

10.

Divaris K, Monda K, North K, Olshan A, Lange E, Moss K . Genome-wide association study of periodontal pathogen colonization. J Dent Res. 2012; 91(7 Suppl):21S-28S. PMC: 3383103. DOI: 10.1177/0022034512447951. View

11.

Nizam N, Basoglu O, Tasbakan M, Nalbantsoy A, Buduneli N . Salivary cytokines and the association between obstructive sleep apnea syndrome and periodontal disease. J Periodontol. 2014; 85(7):e251-8. DOI: 10.1902/jop.2014.130579. View

12.

Barksby H, Lea S, Preshaw P, Taylor J . The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin Exp Immunol. 2007; 149(2):217-25. PMC: 1941943. DOI: 10.1111/j.1365-2249.2007.03441.x. View

13.

Gankovskaya L, Khelminskaya N, Molchanova E, Svitich O . [ROLE OF INNATE IMMUNITY FACTORS IN PERIODONTITIS PATHOGENESIS]. Zh Mikrobiol Epidemiol Immunobiol. 2016; (2):100-7. View

14.

Gemmell E, Seymour G . Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease. Periodontol 2000. 2004; 35:21-41. DOI: 10.1111/j.0906-6713.2004.003557.x. View

15.

Tada H, Matsuyama T, Nishioka T, Hagiwara M, Kiyoura Y, Shimauchi H . Porphyromonas gingivalis Gingipain-Dependently Enhances IL-33 Production in Human Gingival Epithelial Cells. PLoS One. 2016; 11(4):e0152794. PMC: 4825981. DOI: 10.1371/journal.pone.0152794. View

16.

Kursunlu S, Ozturk V, Han B, Atmaca H, Emingil G . Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease. Arch Oral Biol. 2014; 60(1):77-83. DOI: 10.1016/j.archoralbio.2014.08.021. View

17.

Alves C, Andion J, Brandao M, Menezes R . [Pathogenic aspects of the periodontal disease associated to diabetes mellitus]. Arq Bras Endocrinol Metabol. 2007; 51(7):1050-7. DOI: 10.1590/s0004-27302007000700005. View

18.

Ahn S, Cho S, Song J, Kim S, Oh S, Jung S . Caveolin-1 serves as a negative effector in senescent human gingival fibroblasts during Fusobacterium nucleatum infection. Mol Oral Microbiol. 2016; 32(3):236-249. DOI: 10.1111/omi.12167. View

19.

da Luz F, Oliveira A, Borges D, Brigido P, Silva M . The physiopathological role of IL-33: new highlights in bone biology and a proposed role in periodontal disease. Mediators Inflamm. 2014; 2014:342410. PMC: 3945897. DOI: 10.1155/2014/342410. View

20.

Ebersole J, Graves C, Gonzalez O, Dawson 3rd D, Morford L, Huja P . Aging, inflammation, immunity and periodontal disease. Periodontol 2000. 2016; 72(1):54-75. DOI: 10.1111/prd.12135. View