Neutrophils in Tissue Injury and Repair

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 2018 Feb 1

PMID 29383445

Citations 280

Authors

Jing Wang

Affiliations

Soon will be listed here.

Abstract

As one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity and plasticity and novel reparative functions have expanded our understanding of their diverse roles in health and disease. This review summarizes our current understanding of neutrophil-associated tissue injury, highlighting the emerging roles of neutrophil extracellular traps. This review will also focus on scrutinizing the roles of neutrophils in tissue repair and regeneration and will examine data on unexpected aspects of involvement of neutrophils in regulating normal tissue homeostasis.

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References

Gonzalez-Lopez A, Albaiceta G . Repair after acute lung injury: molecular mechanisms and therapeutic opportunities. Crit Care. 2012; 16(2):209. PMC: 3681355. DOI: 10.1186/cc11224. View

Koczulla R, von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T . An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest. 2003; 111(11):1665-72. PMC: 156109. DOI: 10.1172/JCI17545. View

Tirouvanziam R, Gernez Y, Conrad C, Moss R, Schrijver I, Dunn C . Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Proc Natl Acad Sci U S A. 2008; 105(11):4335-9. PMC: 2393742. DOI: 10.1073/pnas.0712386105. View

Pizza F, Peterson J, Baas J, Koh T . Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice. J Physiol. 2004; 562(Pt 3):899-913. PMC: 1665528. DOI: 10.1113/jphysiol.2004.073965. View

Zec K, Volke J, Vijitha N, Thiebes S, Gunzer M, Kurts C . Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages. Pathogens. 2016; 5(1). PMC: 4810136. DOI: 10.3390/pathogens5010015. View

Hasenberg A, Hasenberg M, Mann L, Neumann F, Borkenstein L, Stecher M . Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods. 2015; 12(5):445-52. DOI: 10.1038/nmeth.3322. View

Gaut J, Yeh G, Tran H, Byun J, Henderson J, Richter G . Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proc Natl Acad Sci U S A. 2001; 98(21):11961-6. PMC: 59821. DOI: 10.1073/pnas.211190298. View

Sarris M, Masson J, Maurin D, Van der Aa L, Boudinot P, Lortat-Jacob H . Inflammatory chemokines direct and restrict leukocyte migration within live tissues as glycan-bound gradients. Curr Biol. 2012; 22(24):2375-82. DOI: 10.1016/j.cub.2012.11.018. View

Campbell E, Bruyninckx W, Kelly C, Glover L, McNamee E, Bowers B . Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014; 40(1):66-77. PMC: 3951457. DOI: 10.1016/j.immuni.2013.11.020. View

10.

Chen G, Nunez G . Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010; 10(12):826-37. PMC: 3114424. DOI: 10.1038/nri2873. View

11.

Ardi V, Kupriyanova T, Deryugina E, Quigley J . Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis. Proc Natl Acad Sci U S A. 2007; 104(51):20262-7. PMC: 2154419. DOI: 10.1073/pnas.0706438104. View

12.

Neirinckx V, Coste C, Franzen R, Gothot A, Rogister B, Wislet S . Neutrophil contribution to spinal cord injury and repair. J Neuroinflammation. 2014; 11:150. PMC: 4174328. DOI: 10.1186/s12974-014-0150-2. View

13.

Reber L, Gillis C, Starkl P, Jonsson F, Sibilano R, Marichal T . Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide. J Exp Med. 2017; 214(5):1249-1258. PMC: 5413333. DOI: 10.1084/jem.20161238. View

14.

Nemeth T, Mocsai A . Feedback Amplification of Neutrophil Function. Trends Immunol. 2016; 37(6):412-424. DOI: 10.1016/j.it.2016.04.002. View

15.

Nathan C . Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006; 6(3):173-82. DOI: 10.1038/nri1785. View

16.

Heijink I, Pouwels S, Leijendekker C, de Bruin H, Zijlstra G, van der Vaart H . Cigarette smoke-induced damage-associated molecular pattern release from necrotic neutrophils triggers proinflammatory mediator release. Am J Respir Cell Mol Biol. 2014; 52(5):554-62. DOI: 10.1165/rcmb.2013-0505OC. View

17.

Kruger P, Saffarzadeh M, Weber A, Rieber N, Radsak M, von Bernuth H . Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog. 2015; 11(3):e1004651. PMC: 4357453. DOI: 10.1371/journal.ppat.1004651. View

18.

Nourshargh S, Alon R . Leukocyte migration into inflamed tissues. Immunity. 2014; 41(5):694-707. DOI: 10.1016/j.immuni.2014.10.008. View

19.

Silvestre-Roig C, Hidalgo A, Soehnlein O . Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood. 2016; 127(18):2173-81. DOI: 10.1182/blood-2016-01-688887. View

20.

Tierney M, Aydogdu T, Sala D, Malecova B, Gatto S, Puri P . STAT3 signaling controls satellite cell expansion and skeletal muscle repair. Nat Med. 2014; 20(10):1182-6. PMC: 4332844. DOI: 10.1038/nm.3656. View