Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins

Overview

Journal Biochemistry

Specialty Biochemistry

Date 2018 Jan 31

PMID 29381858

Citations 18

Authors

Lisa S Cunden

Elizabeth M Nolan

Affiliations

Soon will be listed here.

Abstract

The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This Perspective highlights recent advances in the Zn(II) coordination chemistry of these three proteins, as well as select studies that evaluate Zn(II) sequestration as an antimicrobial mechanism.

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