Sex Differences in Obesity Related Cancer Incidence in Relation to Type 2 Diabetes Diagnosis (ZODIAC-49)

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Jan 26

PMID 29370205

Citations 3

Authors

Dennis Schrijnders

Steven H Hendriks

Nanne Kleefstra

Pauline A J Vissers

Jeffrey A Johnson

Geertruida H de Bock

Henk J G Bilo

Gijs W D Landman

Affiliations

Soon will be listed here.

Abstract

Background: Diabetes and obesity seem to be partly overlapping risk factors for the development of obesity-related cancer (mainly breast, prostate and colorectal cancer) in patients with type 2 diabetes (T2DM). In the general population, women have a lower risk for obesity-related cancer compared to men. Previous studies involving cardiovascular disease have shown that T2DM eliminates a female advantage of lower CVD risk in the general population compared to men. It is unclear whether the same could be true for obesity-related cancer. This study aimed to this investigate obesity-related cancer incidence in women and men known with T2DM as compared to the Dutch general population.

Methods: This study included 69,583 patients with T2DM selected from a prospective primary care cohort, which was linked to the Dutch National Cancer Registry to obtain cancer specific data. Obesity-related cancers included liver, kidney, colorectal, gallbladder, pancreas, ovarian, endometrial, advanced prostate cancer, post-menopausal breast cancer and oesophageal adenocarcinoma. Primary outcome was sex-stratified, age and year of cancer diagnosis adjusted standardized incidence ratios (SIRs) for three time periods: 5 years before, the year after diagnosis and the next 4 years after T2DM diagnosis. The Dutch general population was used as reference group.

Results: Women with T2DM were at an increased risk for obesity-related cancer compared to women in the general population already 5 years before diabetes diagnosis (SIR 1.77; 95%CI: 1.63-1.91). In both men and women, there was a peak in obesity-related cancer incidence following diabetes diagnosis (SIR: 1.38; 95%CI 1.11-1.64 and SIR: 2.21; 95%CI 1.94-2.30, respectively). From the second to the fifth year after diabetes diagnosis the obesity-related cancer incidence was higher in women compared to women in the general population (SIR: 2.12; 95%CI 1.94-2.30).

Conclusions: Women with T2DM seem to have a substantially higher obesity-related cancer risk. As opposed to men, in women this risk was already increased years before diabetes diagnosis. These results could imply that a relative advantage of women in the general population with regard to cancer risk is lost in women with T2DM.

Citing Articles

Role of Serum Lipids, Blood Glucose and Blood Pressure in Breast Cancer Risk for Women with Type 2 Diabetes Mellitus.

Zhang F, de Bock G, Denig P, Landman G, Zhang Q, Sidorenkov G Clin Epidemiol. 2023; 15:109-121.

PMID: 36718225 PMC: 9884051. DOI: 10.2147/CLEP.S386471.

Are the factors associated with overweight/general obesity and abdominal obesity different depending on menopausal status?.

Chen J, Guo J, Mao P, Yang J, Jiang S, He W PLoS One. 2021; 16(2):e0245150.

PMID: 33539356 PMC: 7861369. DOI: 10.1371/journal.pone.0245150.

Activation of cancer-related and mitogen-activated protein kinase signaling pathways in human mature osteoblasts isolated from patients with type 2 diabetes.

Kuroiwa T, Matsumoto M, Kato R, Nimura A, Yoshii T, Okawa A Bone Rep. 2019; 10:100199.

PMID: 30891471 PMC: 6406057. DOI: 10.1016/j.bonr.2019.100199.

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