High Glucose Contributes to the Proliferation and Migration of Non-small Cell Lung Cancer Cells Via GAS5-TRIB3 Axis

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 Jan 26

PMID 29367413

Citations 15

Authors

Cheng-Zhi Ding

Xu-Feng Guo

Guo-Lei Wang

Hong-Tao Wang

Guang-Hui Xu

Yuan-Yuan Liu

Zhen-Jiang Wu

Yu-Hang Chen

Jiao Wang

Wen-Guang Wang

Affiliations

Soon will be listed here.

Abstract

Despite the growing number of studies exhibited an association of diabetes mellitus (DM) and lung cancer progression, the concrete mechanism of DM aggravating lung cancer has not been elucidated. This study was to investigate whether and how high glucose (HG) contribute to the proliferation and migration of non-small cell lung cancer (NSCLC) cells in vitro. In the present study, we confirmed that HG promoted the proliferation and migration of NSCLC cells, and also induced an anti-apoptosis effect on NSCLC cells. Moreover, HG inhibited the expression of GAS5 in NSCLC cells but elevated the protein level of TRIB3. GAS5 overexpression promoted the degradation of TRIB3 protein by ubiquitination and inhibited the HG induced-proliferation, anti-apoptosis and migration of NSCLC cells. Importantly, TRIB3 overexpression reversed the effects of GAS5 on the HG-treated NSCLC cells. Taken together, down-regulated GAS5 by HG significantly enhanced the proliferation, anti-apoptosis and migration in NSCLC cells through TRIB3, thus promoting the carcinogenesis of NSCLC.

Citing Articles

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