The Neonatal Anti-viral Response Fails to Control Measles Virus Spread in Neurons Despite Interferon-gamma Expression and a Th1-like Cytokine Profile

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2018 Jan 26

PMID 29366594

Citations 4

Authors

Priya Ganesan

Manisha N Chandwani

Patrick S Creisher

Larissa Bohn

Lauren A ODonnell

Affiliations

Soon will be listed here.

Abstract

Neonates are highly susceptible to viral infections in the periphery, potentially due to deviant cytokine responses. Here, we investigated the role of interferon-gamma (IFNγ), a key anti-viral in the neonatal brain. We found that (i) IFNγ, which is critical for viral control and survival in adults, delays mortality in neonates, (ii) IFNγ limits infiltration of macrophages, neutrophils, and T cells in the neonatal brain, (iii) neonates and adults differentially express pathogen recognition receptors and Type I interferons in response to the infection, (iv) both neonates and adults express IFNγ and other Th1-related factors, but expression of many cytokines/chemokines and IFNγ-responsive genes is age-dependent, and (v) administration of IFNγ extends survival and reduces CD4 T cell infiltration in the neonatal brain. Our findings suggest age-dependent expression of cytokine/chemokine profiles in the brain and distinct dynamic interplays between lymphocyte populations and cytokines/chemokines in MV-infected neonates.

Citing Articles

The Neonatal Immune System and Respiratory Pathogens.

Sedney C, Harvill E Microorganisms. 2023; 11(6).

PMID: 37375099 PMC: 10301501. DOI: 10.3390/microorganisms11061597.

Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells.

Bakre A, Duffy C, Abdullah H, Cosby S, Tripp R Front Microbiol. 2021; 12:671852.

PMID: 34539595 PMC: 8446675. DOI: 10.3389/fmicb.2021.671852.

Type II interferon signaling in the brain during a viral infection with age-dependent pathogenesis.

Creisher P, Chandwani M, Kamte Y, Covvey J, Ganesan P, ODonnell L Dev Neurobiol. 2020; 80(7-8):213-228.

PMID: 32866337 PMC: 8513332. DOI: 10.1002/dneu.22778.

Understanding the Role of Antiviral Cytokines and Chemokines on Neural Stem/Progenitor Cell Activity and Survival.

Chandwani M, Creisher P, ODonnell L Viral Immunol. 2018; 32(1):15-24.

PMID: 30307795 PMC: 6350063. DOI: 10.1089/vim.2018.0091.

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